Title Povezanost nutritivnog i parodontološkog statusa s debljinom intima - medije karotidnih arterija u bolesnika s transplantiranim bubregom Title (english) Assotiations of nutritional and periodontal status with the intima-media thickness of carotid arteries in kidney transplant recipients Author Maja Dodig Novaković Mentor Josipa Radić (komentor)Mentor Sanja Lovrić-Kojundžić (komentor)Committee member Duška Glavaš (predsjednik povjerenstva)Committee member Ivana Štula (član povjerenstva)Committee member Ivan Galić (član povjerenstva)Granter University of Split Defense date and country 2025-01-27, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Universal decimal classificationUDC ) 616 - Pathology. Clinical medicine Abstract UVOD: Cilj ovog istraživanja bio je procijeniti IMT kao surogatnog markera ateroskleroze i analizirati moguće čimbenike rizika za povećanje vrijednosti IMT-a kod bolesnika s transplantiranim bubregom te analizirati njegovu povezanost s nutritivnim i parodontološkim statusom. Ovo istraživanje je analiziralo povezanost adropina s parametrima sastava tijela u bolesnika s TB-om, posebno naglašavajući razlike između spolova. MATERIJALI I METODE: U ovo je istraživanje uključeno 93 bolesnika s TB-om.
... More Prikupljeni su podaci o kliničkim i laboratorijskim parametrima, sastavu tijela, antropometriji, mjerenjima krajnjih produkata glikacije, krvnom tlaku i krutosti arterija. Svi sudionici podvrgnuti su ultrazvučnom pregledu IMT-a i procjeni parodontološkog statusa. Razine adropina u serumu određene su s pomoću komercijalnog ELISA testnog kompleta. REZULTATI: TB s vrijednosti IMT ≥ 0,9 bili su značajno stariji, imali su nižu razinu ukupnog kolesterola, masnog tkiva i manji broj zuba. Također su imali značajno više vrijednosti PWV-a, RI-a i EDV-a. Potvrdili smo pozitivnu korelaciju između vrijednosti IMT-a i trajanja dijalize, dobi, parametara krutosti krvnih žila, AGE-a, RI-a i CAL-a. Regresijski model je pokazao da je IMT u TB-u povezan s većom krutošću krvnih žila, pothranjenosti i manjim brojem zuba. Bolesnici s TB i IMT ≥ 0.9 mm imali su manji broj zuba i veću vrijednost CAL-a. Ti parodontološki parametri su se dokazali kao najvažniji prediktori IMT-a u TB. Analiza je obuhvatila podskupinu bolesnika od 59 TB-a (28 žena u postmenopauzi i 31 muškarca), koje su dodatno kategorizirane prema vrijednostima adropina u odnosu na prosječnu vrijednost svake skupine. Univarijatna regresijska analiza pokazala je negativnu povezanost razina adropina s većinom antropometrijskih i parametara sastava tijela u muških TB-a. Suprotno tome, razina adropina u serumu bila je negativno povezana samo s faznim kutem u ženskih TB-ova. Multivarijatna regresija analiza pokazala je da su u ženskoj skupini TB-a skeletna mišićna masa i fazni kut bili jedini negativni prediktori, dok su u muškaraca negativni prediktori bili ITM i udio tjelesne vode. ZAKLJUČAK: Rezultati našeg istraživanja sugeriraju da su nutritivni i parodontološki status povezani s većom vrijednosti IMT-a kod TB-a. Nalazi sugeriraju da adropin može imati različit utjecaj na metaboličku homeostazu u TB-ova s obzirom na spol i može se smatrati negativnim prediktorom sastava tijela u ovoj skupini bolesnika. Glavna snaga ovog našeg istraživanja bolesnika s TB-om je u tome što je ovo prva studija analize povezanosti parodontoloških, nutritivnih parametara i medijatora upale poput adropina sa zadebljanjem intima-medije kao zamjenskog markera subkliničke ateroskleroze i KV rizika. Less Abstract (english) INTRODUCTION: This study aimed to evaluate intima-media thickness (IMT) as a surrogate marker for atherosclerosis and to analyze potential risk factors associated with increased IMT values in kidney transplant patients as well as to analyze its connection with nutritional and parodontal status. This study analyzed the relationship between adropin levels and body composition parameters in kidney transplant patients, with a particular focus on gender differences. MATHERIALS AND METHODS: This
... More study included 93 kidney transplant patients. Clinical and laboratory parameters, body composition, anthropometrics, advanced glycation end products (AGEs), blood pressure, and arterial stiffness measurements were collected. All participants underwent ultrasound examination of IMT and periodontal assessment. Adropin levels in serum determined with comercial ELISA test set. RESULTS: Patients with IMT values ≥ 0.9 mm were significantly older, had lower levels of total cholesterol, less adipose tissue, and fewer teeth. They also showed significantly higher values for pulse wave velocity (PWV), resistive index (RI), and end-diastolic velocity (EDV). We confirmed a positive correlation between IMT values and dialysis duration, age, vascular stiffness parameters, AGE, RI, and clinical attachment loss (CAL). Regression modeling indicated that IMT in kidney transplant recipients was associated with higher vascular stiffness, malnutrition, and a lower number of teeth. Kidney transplant recipients with IMT ≥ 0.9 mm had less number of teeth i higher value of CAL. These parodontal paramete have proven to be the most important predictors of IMT in KTR. The analysis included a subset of 59 transplant patients (28 postmenopausal women and 31 men), further categorized based on adropin values relative to the average within each group. Univariate regression analysis revealed a negative association between adropin levels and most anthropometric and body composition parameters in male transplant patients. In contrast, serum adropin levels were negatively associated only with phase angle in female patients. Multivariate regression analysis showed that skeletal muscle mass and phase angle were the only negative predictors in the female group, while in men, body mass index (BMI) and body water percentage were negative predictors. CONCLUSION: Our findings suggest that nutritional and periodontal status are associated with higher IMT values in kidney transplant patients. These findings suggest that adropin may have a sex-specific impact on metabolic homeostasis in kidney transplant patients and may be considered a negative predictor of body composition within this patient group. The primary strength of this study on kidney transplant recipients lies in being the first to analyze the association between periodontal and nutritional parameters and inflammatory mediators like adropin with intima-media thickness as a marker of subclinical atherosclerosis and CV risk. Less Keywords
kronična bubrežna insuficijencija
transplantacija bubrega
debljina karotidne intima-medije
nutritivni status
parodontitis
Keywords (english)
Chronic Renal Insufficiency
Kidney Transplantation
Carotid Intima-Media Thickness
Nutritional Status
Periodontitis
Language croatian URN:NBN urn:nbn:hr:171:097118 Study programme Title: Biology of Neoplasms Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2025-01-28 09:11:09
