| Abstract | Cilj istraživanja: Analizirati epidemiološke karakteristike pacijenata sa karcinomom pluća i utvrditi histološke tipove istih u razdoblju od 2010. do 2015. u KBC Split.
Materijali i metode: Retrospektivno epidemiološko istraživanje. Uzorak pacijenata obuhvaća sve pacijente s dijagnozom karcinoma pluća na Odjelu za patologiju, sudsku medicinu i citologiju KBC–a Split. Pacijentima su određeni dob (godine), spol (muško/žensko), histološki tip karcinoma, imunohistokemijska bojanja korištena u dijagnostici i vrsta dijagnostičkog zahvata.
Rezultati: Analizirano je ukupno 1344 pacijenta, od kojih je bilo 1008 muškaraca ( 75%), i 336 žena ( 25%). Prosječna dob muškarca iznosila je 66 godina, a za žene 65 godina, te nije bilo značajne razlike u dobi ispitanikan (P=0,0913). Najučestaliji histološki tip karcinoma pluća bio je adenokarcinom (39,4%), a drugi po učestalosti karcinom pločastih stanica (33,0%). Najučestaliji histološki tip karcinoma pluća kod muškaraca je bio karcinom počastih stanica, dok je na drugom mjestu adenokarcinom. Kod žena, najučestaliji histološki tip karcinoma pluća je bio adenokarcinom, dok je karcinom pločastih stanica na drugom mjestu. Najučestaliji podtip adenokarcinoma pluća kod muškaraca je bio solidni (51,3%), a kod žena acinarni podtip (42,86%). Najveći broj uzoraka, njih 1237 (92,03%), za patohistološku analizu je dobiven transbronhalne biopsije. Najčešće korištena primarna antitijela bila su CK 5/6, CK 7, TTF-1 i napsin.
Zaključak: U KBC Split većina pacijenata sa dijagnozom malignog tumora pluća je muškog spola. U ovom razdoblju došlo je do povećanja dijagnosticiranih slučajeva te se pojavila promjena incidencije karcinoma pluća po spolu. Najzastupljeniji histološki tip je adenokarcinom. Učestalost histoloških tipova karcinoma pluća obzirom na spol je različita. U muškaraca najzastupljeniji je karcinom pločastih stanica, a u žena adenokarcinom. Uzorak za patohistološki analizu dobiven je transbronhalnom biopsijom u 92%, a najčešće korištena primarna antitijela su CK 5/6, CK 7, TTF-1 i napsin. |
| Abstract (english) | Objectives: To analyze epidemiologic characteristics of patients with lung carcinoma and histological types of the former in KBC Split from 2010 till 2015.
Materials and Methods: A retrospective epidemiologic research has been made. Patients’ samples included all patients diagnosed with lung carcinoma at the Department of pathology, forensic medicine and cytology KBC Split. Age (years), sex (male/female), histological type of carcinoma, immunohistochemistry and type of diagnostic procedure were determined.
Results: Records of 1344 patients were analyzed. Study included 1008 men (75%) and 336 women (25%). Average age of men was 66 years and women 65 years which was statistically insignificant (P= 0, 0913). The most common histological type of lung carcinoma was adenocarcinoma (39, 4%) and the second most common was squamous cell carcinoma (33%). The most common histological type of lung carcinoma for men was squamous cell carcinoma while adenocarcinoma was on the second place. When talking about women the most common histological type of lung cancer was adenocarcinoma and squamous cell carcinoma was on the second place. The most common adenocarcinoma subtype for men was solid (51, 3%) and for women was acinar subtype (42, 86%). Most of samples, 1237 (92, 03%), for patohistological analysis were taken with transbronhial bronchoscopy. Most frequently used primary antibodies where CK 5/6, CK 7, TTF-1 and napsin.
Conclusion: In KBC Split most of the patients with lung carcinoma were men. In this period the number of diagnosed cases increased and also some changes in incidence of lung carcinoma by sex happened. The most common histological type of lung carcinoma was adenocarcinoma. Incidence of histological types by sex is different. The most common histological type of lung carcinoma for men was squamous cell carcinoma, while in women it was adenocarcinoma. Most of samples for patohistological analises were taken with transbronhial bronhoskopy and most frequently used primary antibodies where CK 5/6, CK 7, TTF-1 and napsin. |
