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master's thesis
Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine
2016. urn:nbn:hr:171:026245
Nikolić, Zrinka
University of Split
School of Medicine
Internal medicine

Cite this document

Nikolić, Z. (2016). Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:026245

Nikolić, Zrinka. "Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine." Master's thesis, University of Split, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:171:026245

Nikolić, Zrinka. "Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine." Master's thesis, University of Split, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:171:026245

Nikolić, Z. (2016). 'Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine', Master's thesis, University of Split, School of Medicine, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:026245

Nikolić Z. Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine [Master's thesis]. Split: University of Split, School of Medicine; 2016 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:171:026245

Z. Nikolić, "Klinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine", Master's thesis, University of Split, School of Medicine, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:171:026245

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Metadata
TitleKlinička obilježja bolesnika s HLA-B35 pozitivnim spondiloartritisom u Splitsko-dalmatinskoj županiji u razdoblju od 2005. do 2015. godine
Title (english)Clinical presentation of patients with HLA-B35 positive spondyloarthritides in Split-Dalmatia County for the period from 2005 to 2015
AuthorZrinka Nikolić
MentorDaniela Marasović Krstulović (mentor)
GranterUniversity of Split
School of Medicine
(Internal medicine)
Split
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
CILJ ISTRAŽIVANJA: Cilj ovog istraživanja bio je ispitati klinička obilježja, laboratorijske parametre i primijenjenu terapiju u HLA-B35 pozitivnih bolesnika sa spondiloartritisom u Splitsko-dalmatinskoj županiji. METODE: Istraživanje je obuhvatilo 64 bolesnika s HLA-B35 pozitivnim spondiloartritisom u razdoblju od početka 2005. godine do kraja 2015. godine. Podatci su prikupljeni iz ambulanti, stacionara i dnevne bolnice Zavoda za reumatologiju i kliničku imunologiju Klinike za unutarnje bolesti Kliničkog bolničkog centra Split. Bolesnici su uključeni u istraživanje na temelju ASAS klasifikacijskih kriterija za aksijalni ili periferni spondiloartritis. REZULTATI: Omjer žena i muškaraca bio je 4,82. 68,7% bolesnika imalo je aksijalne manifestacije, a 90,6% periferne. Zahvaćenost oka javila se kod 14,1% bolesnika, a kože i adneksa u 20,3%. Niti jedan bolesnik nije imao upalnu bolest crijeva. 15,6% bolesnika bili su HLA-B27 pozitivni. Laboratorijske vrijednosti CRP i SE nisu se značajno razlikovale između bolesnika s aksijalnim i perifernim manifestacijama. NSAR je koristilo 81,2% bolesnika, DMARD 75%, fizikalnu terapiju 48,4%, sistemske glukokortikoide 29,7%, NSAR primijenjene lokalno 25% te glukokortikoide primijenjene lokalno 4,7% bolesnika. ZAKLJUČCI: Značajan udio bolesnika imao je aksijalne i periferne manifestacije. Zastupljenost izvanzglobnih manifestacija bila je niska. Malen je udio bolesnika s pozitivnim HLA-B27 antigenom. Najčešće korištena terapija bili su NSAR.
Abstract (english)
OBJECTIVES: The aim of this study was to assess clinical features, laboratory parameters and treatment of the patients with HLA-B35 positive spondyoarthritides in Split-Dalmatia County. METHODS: The study included 64 patients with HLA-B35 positive spondyloarthritis. The data were collected from archives of the Department of Rheumatology and Clinical Immunology, University Hospital Split for the period from January 2005 to December 2015. All patients were evaluated by the ASAS classification criteria for the axial or peripheral spondyloarthritis. RESULTS: A female predominance with a female/male ratio of 4,82/1 was documented. 68,7% of patients exhibited axial manifestations of the disease, while 90,6% had peripheral manifestations. 14,1% of the 64 patients showed eye involvement and 20,3% skin involvement. Not a single patient had inflammatory bowel disease. 15,6% of patients were HLA-B27 positive. The difference in laboratory values of C-reactive protein and erythrocyte sedimentation rate was not statistically significant between the patients who exhibited axial and peripheral involvement. NSAIDs were used by 81,2% of patients included in the study, followed by DMARDs 75%, physical therapy 48,4%, systemic glucocorticoids 29,7%, topical NSAIDs 25% and glucocorticoid injections 4,7%. CONCLUSION: Our data suggest that there is a significant proportion of patients having axial and peripheral manifestations among HLA-B35 positive patients with spondyloarthritis. On the other hand only small number of patients showed extraarticular involvement. Also, the frequency of concomitant HLA-B27 positivity was low. The most common treatment were NSAIDs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:026245
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-10-06 12:22:13