Objectives: To describe the epidemiological patterns of tuberculosis in Split-Dalmatia county in the period 2003.-2016. Materials and methods: A retrospective analysis of epidemiological patterns of tuberculosis in Split-Dalmatia county was done. All tuberculosis patients registered by the county's Public Health Institute in the period 2003.-2016. were included in the study. In total, 926 tuberculosis patients were analyzed. Results: The incidence rates showed a continuous decrease in the period 2003.-2016. and during the last six years the rates were always below or slighlty above the rate of 10/100 000. Even though the incidence rates were the highest in the Hinterland and the lowest on the Islands at the beginning of this study, during the last 6 years (2011.-2016.) the incidence rates in the Hinterland and on the Islands have become almost equal (mostly due to significant decrease of the incidence rates in the Hinterland) while the incidence rates at the Coastline have become the lowest. The incidence rates increase with age. Men are almost twice as likely to suffer from tuberculosis than women. Pulmonary tuberculosis is by far the most common presentation of the disease (85,10% of all examined patients). A bacteriologically confirmed tuberculosis has been found in 71,92% of the cases. In total, 40,82% of the patients were sputum smear-positive, which means they were highly contagious. Anti-tuberculosis drug resistance was found in 4,35% of all cases and it was mostly monoresistance, most often to isoniazide. Only two cases of MDR-TB has been notified. Conclusion: Epidemiological situation regarding tuberculosis in Split-Dalmatia county is favourable. Nevertheless, we should continue to be vigilant and work intensely on the implementation and strengthening of anti-tuberculosis measures in order to eliminate tuberculosis as a public health problem.