| Abstract | Cilj: Cilj istraživanja bio je ispitati učestalost određenih patohistoloških promjena karakterističnih za OLP u ispitanika s različitim kliničkim oblicima OLP-a te utvrditi postoji li razlika u učestalosti određenih patohistoloških promjena između ispitanika s različitim kliničkim oblicima OLP-a.
Materijal i metode: U istraživanje su uključena 42 pacijenata s kliničkom dijagnozom OLP-a. Ispitanicima je nakon anamneze i kliničkog pregleda uzet biopsijski uzorak patološki promijenjene oralne sluznice. Sve bioptate pregledao je specijalist patologije te izdao pisani patohistološki nalaz u kojem su opisane pojedine patohistološke promjene karakteristične za OLP .
Rezultati: Rezultati ovog istraživanja pokazali su kako je u ukupno 42 ispitanika s kliničkom dijagnozom OLP-a najzastupljeniji bio retikularni oblik, utvrđen u njih 19 (45,24 %), odnosno kombinacija retikularnog s drugim kliničkim oblicima u njih također 19 (45,24 %). Prema patohistološkom nalazu hipekeratoza je nađena u 26 (61,91 %), odebljanje granularnog sloja u 1 (2,38 %), akantoza u spinoznom sloju u 11 (26,19 %), limfociti u spinoznom sloju u 10 (23,81 %), koloidna tjelešca u 10 (23,81 %), vakuolarna degeneracija bazalnog sloja u 1 (2,38 %), stanični infiltrat u bazalnom sloju u 8 (19,05 %), zupci pile u 12 (28,57 %), vrpčaste nakupine limfocita u lamini propriji u 41 (97,62 %) i plazma stanični infiltrat u lamini propriji u 2 (4,76 %) ispitanika.
Zaključci: Temeljem dobivenih rezultata može se zaključiti kako nema značajne razlike u učestalosti određenih patohistoloških promjena između ispitanika s različitim kliničkim oblicima OLP-a, osim u slučaju hiperkeratoze koja se opisuje u 63,2 % uzoraka retikularnog oblika, a u nijednom (0 %) uzorku erozivnog OLP-a. |
| Abstract (english) | Objective: The aim of this study was to evaluate the incidence of certain OLP characteristic pathohistological changes in patients with different clinical forms of OLP and to determine whether there is a difference in the incidence of certain pathohistological changes between patients with different clinical forms of OLP.
Material and methods: The study included 42 patients with a clinical diagnosis of OLP. After anamnesis and clinical examination, a biopsy sample of pathologically changed oral mucosa was taken. All biopsies were reviewed by a specialist of pathology and released a written pathohistological result that describes some pathohistological changes characteristic of OLP.
Results: The results of this study show that among a total of 42 patients with clinical diagnosis of OLP, the most common was the recitural form that was determined in 19 (45,24 %), or the combination of the reticular and other clinical forms also in 19 (45,24 %) subjects. According to the pathohistological findings, hyperkeratosis was found in 26 (61,91 %), thickening of the granular layer in 1 (2,38 %), acanthosis in stratum spinosum 11 (26,19 %), lymphocytes in stratum spinosum in 10 (23,81 %), colloid bodies in 10 (23,81 %) , vacuolar degeneration of basal cells in 1 (2,38 %), cell infiltrate in basal layer in 8 (19,05 %) , papillomatosis in 12 (28,57 %), lymphocyte infiltration in lamina propria in 41(97,62 %) and plasma cell infiltrate in lamina propria in 2 (4,76 %) patients.
Conclusion: Based on the results, it can be concluded that there is no significant difference in the frequency of certain pathohistological changes between patients with different clinical forms of OLP, except in the case of hyperkeratosis described in 63.2% specimens of reticular form, and none (0%) of erosive OLP. |
