Aim of the thesis: The primary aim of this research in medical anti-glaucoma therapy is to find out the total number of anti-glaucoma drugs in Split-Dalmatia county in the last 5 years, especially with regards to consumption of original anti-glaucoma drugs against their generic counterparts and comparison between fixed (combined) and mono therapy. Also we want to show if the prescription of prostaglandin analogues has risen through the years. Patients and methods: In this research we used data of the number of anti-glaucoma drugs used in Split- Dalmatia County between the years of 2012 and 2016 from glaucoma patients. The data is collected in pharmacies of the county. In this research the data gathered from the pharmacies have been retrospectively statistically and analytically analysed. The data was processed in Microsoft Excel and Microsoft Word programs. In the processing of the data we used the Pearson correlation coefficient. The results were interpreted at a significance level of p<0.05. The data was processed and shown with the help of Microsoft Excel and Microsoft Word programs. Results: In our study we showed that of the total amount of consumed anti-glaucoma drugs (n=784123), the highest amount takes consumption of original mono-component drugs (n=554530 or 71%) which makes it 23.7 times more than generic mono-component drugs. The amount of original drugs spent (n= 755335) in Split- Dalmatia county is 26 times higher compared to generic drugs (n=28788). Among original drugs, 73% are monocomponent drugs while 14% are fixed dose combination drugs. Consumption share of the original mono-component drugs shows a decreasing trend from 2012- 2016 while consumption share of the original fixed dose combination drugs shows an increasing trend from 2012- 2016. Also we can see that the amount of consumed original prostaglandin analogues has an increasing trend from 2012-2016 (r=0.8692; P=0.007) and the amount of consumed generic prostaglandin analogues also has an increasing trend from 2012-2016 (r=0.9384; P=0.002). Conclusion: The increasing trend in prescribing prostaglandin analogues, an increasing trend in prescribing fixed-dose combinations and generally much higher sales numbers in original anti-glaucoma medications show the tendency in the Split-Dalmatian counties’ ophthalmological community to follow the guidelines of the European Glaucoma Society.