prikaz prve stranice dokumenta Morphological characteristics of placentas with villitis of unknown etiology
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master's thesis
Morphological characteristics of placentas with villitis of unknown etiology
2018. urn:nbn:hr:171:138554
Narloch, Charlotte
University of Split
School of Medicine
Pathology

Cite this document

Narloch, C. (2018). Morphological characteristics of placentas with villitis of unknown etiology (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:138554

Narloch, Charlotte. "Morphological characteristics of placentas with villitis of unknown etiology." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:138554

Narloch, Charlotte. "Morphological characteristics of placentas with villitis of unknown etiology." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:138554

Narloch, C. (2018). 'Morphological characteristics of placentas with villitis of unknown etiology', Master's thesis, University of Split, School of Medicine, accessed 03 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:138554

Narloch C. Morphological characteristics of placentas with villitis of unknown etiology [Master's thesis]. Split: University of Split, School of Medicine; 2018 [cited 2025 April 03] Available at: https://urn.nsk.hr/urn:nbn:hr:171:138554

C. Narloch, "Morphological characteristics of placentas with villitis of unknown etiology", Master's thesis, University of Split, School of Medicine, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:171:138554

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Metadata
TitleMorphological characteristics of placentas with villitis of unknown etiology
Title (croatian)Morfološke karakteristike posteljica s vilitisom nepoznate etiologije
AuthorCharlotte Narloch
MentorSandra Zekić Tomaš (mentor)
GranterUniversity of Split
School of Medicine
(Pathology)
Split
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Objectives: To investigate morphological characteristics of placentas with villitis of unknown etiology (VUE) and to compare them to normal term placentas without VUE, likewise, to compare placental morphological characteristics within the VUE group with regard to VUE grade. Materials and Methods: This study included 50 placentas diagnosed with VUE and 50 normal term placentas without VUE. Data collection and placental examination was carried out at the University Hospital of Split. VUE... More was diagnosed based on histological examination of the placentas and graded into low grade VUE and high grade VUE. Following lesions due to maternal and fetal blood flow disturbances and fetal and maternal vascular malperfusion were noted together with placental site, umbilical cord insertion and length. Statistical significance was tested using chi-square test, Student’s t-test and Mann-Whitney test. Statistical significance was proved by the P value ≤0.05. Results: From 100 placentas, there was a statistically significant result among clinical findings VUE placentas (n=50) and the control group (n=50) concerning gestational age (P<0.001; Z=5.209) and birth weight (P<0.001; t=6.044). In 42.9% placentas with VUE presented with IUGR (P<0.001; χ2=26.923; DF=1). Gross morphological findings manifested significantly a thinner placental thickness in cm (P<0.001; Z=4.795) and a shorter umbilical cord length in cm (P<0.001; t=5.103) in VUE placentas compared to healthy term placentas. Pathohistological findings manifested a statistically significant difference among funiculitis (P=0.003; χ2=8.609; DF=1) and fetal thrombotic vasculopathy (P=0.023; χ2=5.211; DF=1). Secondly, no statistically significant result differentiating morphological characteristics regarding gross and pathohistological findings in between high grade VUE (n=20) and low grade VUE (n=30) was found. Conclusions: On gross examination a thinner placental thickness and shorter umbilical cord length was found in placentas with VUE compared to healthy term placentas. On pathohistological exam funiculitis and fetal thrombotic vasculopathy implicate a finding of placentas in VUE. Secondly, there is no statistically significant result found among investigated placental findings in the VUE group regarding VUE grading. Less
Abstract (croatian)
Ciljevi: Istražiti morfološke karateristike posteljica s vilitisom nepoznate etiologije (VUE) te dobivene rezultate usporediti s kontrolnom skupinom posteljica. Također, istražiti morfološke karakteristike u skupini VUE posteljica obzirom na histološki gradus vilitisa. Materijali i metode: 50 posteljica s VUE i 50 posteljica iz urednih terminskih trudnoća bez VUE dijagnoze je uključeno u istraživanje. Podatci su prikupljeni na Klinika za ženske bolesti i porode i Klinički zavod za... More patologiju, citologiju i sudsku medicinu KBC Split. Dijagnoza VUE u posteljicama je postavljena na temelju histološkog pregleda istih, te je VUE gradiran kao VUE niskog gradusa i VUE visokoga gradusa. Sve lezije nastale kao posljedica poremecaja cirkulacije majke i dijeteta te lezije koje su posljedica majčine vaskularne malperfuzije (MVM) i fetalne vaskularne malperfuzije (FVM) su zabilježene. Također su prikupljeni podatci o veličini posteljice, dužini i mjestu insercije pupčane vrpce kao i o majčinom i fetalnom upalnom odgovoru. Results: Niža gestacijska dob (P<0,001; Z=5,209), niža porođajna težina (P<0,001; t=6,044), te starija dob majke (P=0,005; t=-2,889) su bili učestaliji u posteljicama s VUE nego u posteljicama kontrolne skupine. 42,9% novorođenčadi u VUE skupini je imalo intrauterini zastoj rasta (IUGR), dok u kontrolnoj skupini nijedno novorođenče nije imalo IUGR (P<0,001; χ2=26,923; DF=1). VUE posteljice su bile tanje (P<0,001; Z=4,795) i imale su kraću pupčanu vrpcu u usporedbi s posteljicama kontrolne skupine (P<0,001; t=5,103). Funikulitis (P=0,003; χ2=8,609; DF=1) i fetalna trombotična vaskulopatija (FTV) (P=0,023; χ2=5,211; DF=1) su bili učestaliji u VUE skupini nego u kontrolnoj skupini posteljica. Nije bilo statistički značajne razlike u morfološkim karakteristikama u VUE skupini posteljica obzirom na histološki gradus VUE. Zaključak: VUE je učestao histološki nalaz posteljica trećeg tromjesečja. Naše istraživanje je pokazalo da posteljice s dijagnozom VUE imaju određene morfološke karakteristike kao i kliničke nalaze u smislu gestacijske dobi, porođajne težine te dobi majke koje su učestalije nego kod posteljica bez VUE. Kako bi se utvrdila točna povezanost navedenih razlika između VUE posteljica i posteljica kontrolne skupine potrebna su daljnja istraživanja. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:138554
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-12 08:14:33
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