| Abstract | Cilj istraživanja: Utvrditi uspješnost identifikacije limfnog čvora čuvara SLNB tehnikom kod pacijenata sa rakom dojke na Klinici za kirurgiju, Zavodu za plastičnu, rekonstrukcijsku, estetsku kirurgiju i opekline KBC Split. Odrediti lokalizacije tumora i SLNB procedure kod pacijenata sa rako dojke. Odrediti patohistološke karakteristike raka dojke kod pacijenata podvrgnutih SLNB proceduri. Usporediti patohistološke karakteristike raka dojke pacijenata ovisno o rezultatima nalaza SLNB-a.
Ispitanici i metode: Provedeno je retrospektivno istraživanje na Klinici za kirurgiju, Zavodu za plastičnu, rekonstrukcijsku, estetsku kirurgiju i opekline KBC Split, u kojem su uključena 83 pacijenta. Svi pacijenti bili su žene. Uključeni su zbog dijagnoze raka dojke sa učinjenom SLNB procedurom. Svim ispitanicima zabilježen je spol, dob, lokalizacija tumora, lokalizacija SLNB-a, KI67 proliferacijski faktor, HER2 receptor, estrogenski receptor te progesteronski receptor. Podaci su uneseni u programski paket Microsoft Office Excel za izradu tabličnog prikaza. Sve su statističke analize provedene koristeći programski paket SOFA (Statistics Open For All) Statistics verzija 1.4.6. (Paton-Simpson & Associates Ltd, Mount Albert, Auckland, NZ).
Rezultati: Uspješnost identifikacije limfnog čvora čuvara u našem istraživanju iznosila je 94,31% na 88 učinjenih biopsija. Pet limfnih čvorova (5,68%) nije identificirano SLNB procedurom. Pozitivnih limfnih čvorova čuvara identificirano je 24 (28,91%,) a negativnih 59 (71,08%). SLNB procedura na Klinici za kirurgiju, Zavodu za plastičnu, rekonstrukcijsku, estetsku kirurgiju i opekline KBC Split, pokazala je slične rezultate kao i relevantna literatura. Tumor je bio lokaliziran 49,40% u desnoj dojci, 43,37% u lijevoj, 3,61% bilateralno, 2,41% metastatski te 1,20% nedefinirane lokalizacije. SLNB procedura izvođena je 45,45% desno aksilarno, 43,18% lijevo aksilarno, 5,58% bilateralno aksilarno te 5,68% nedefinirane lokalizacije. Nije pronađena statistički značajna razlika među promatranim skupinama kod: KI67 proliferacijskog faktora (p=0,738), HER2 receptora (p=0,433), estrogenskih receptora (p=0,936) te progesteronskih receptora (p=0,602). 53
Zaključak: Ovo je istraživanje usporedilo rad SLNB procedure na Klinici za kirurgiju, Zavodu za plastičnu, rekonstrukcijsku, estetsku kirurgiju i opekline KBC Split i relevantnu literaturu te potvrdilo hipotezu. Patohistološki rezultati uspoređenih skupina pronađeni u ovom radu mogu biti temeljem daljnje rasprave te je svakako potrebno u daljnjim istraživanjima uključiti veći broj ispitanika te izbjeći nedostatke koje smo primjetili u našem istraživanju. |
| Abstract (english) | Objectives: To determine the success of lymph node sentinel identification with the SLNB method for breast cancer patients at the Surgical Clinic's Department for plastic, reconstructive, aesthetic and burns surgery of University Hospital of Split. The intent is also to determine localizations of tumors and SLNB procedures for patients with breast cancer, as well as histopathological characteristics of breast cancer for patients who have undergone the SLNB procedure and compare histopathological characteristics of breast cancer between patients depending on the results of the SLNB tests.
Study design: Retrospective observational study.
Examinees and methods: A retrospective research was conducted at the Surgical Clinic's Department for plastic, reconstructive, aesthetic and burns surgery of University Hospital of Split, which included 83 patients. All of the patients were women. They were included because of the breast cancer they were diagnosed with using the SLNB procedure. All of the examinees were registered by gender, age, tumor localization, SLNB localization, KI67 proliferative factor, HER2 receptor, estrogen receptor and progesterone receptor. The data was stored in the Microsoft Office Excel spreadsheet creation program package. All statistical analyses were conducted using the SOFA Statistics (Statistics Open For All) program package, version 1.4.6. (Paton-Simpson & Associates Ltd, Mount Albert, Auckland, NZ).
Results: The success rate of identifying the lymph node sentinel within our research was 94,31% in 88 conducted byopsies. Five lymph nodes (5,68%) were not identified by the SLNB procedure. Twenty-four (28,91%) positive sentinel lymph nodes were identified as well as 59 (71,08%) negative ones. The SLNB procedure at the Surgical Clinic's Department for plastic, reconstructive, aesthetic and burns surgery of University of Split has shown results similar to those in relevant literature. The percentage of tumors identified in the right breast was 49,40%, 43,37% in the left, 3,61% bilaterally, 2,41% metastatically and 1,20% was of 56
unidentified localization. The SLNB procedure was conducted 45,45% axillary right, 43,18% axillary left, 5,58% bilaterally axillary and 5,68% was of unidentified localization. Statistically significant difference between observed groups was not found in the KI67 proliferative factor (p=0,738), HER2 receptors (p=0,433), estrogen receptors (p=0,936) and progesteron receptors (p=0,602).
Conclusion: This research compared the work of the SLNB procedure at the Surgical Clinic's Department for plastic, reconstructive, aesthetic and burns surgery of University Hospital of Split and relevant literature and confirmed the hypothesis. Histopathological results of the compared groups found within this work can become the basis for further discussion, and it is certainly necessary to include a larger number of examinees in further research and avoid shortcomings registered within our own. |
