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master's thesis
Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.
2018. urn:nbn:hr:171:673803
Žuvan, Leona
University of Split
School of Medicine
Internal medicine

Cite this document

Žuvan, L. (2018). Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017. (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:673803

Žuvan, Leona. "Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:673803

Žuvan, Leona. "Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:673803

Žuvan, L. (2018). 'Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.', Master's thesis, University of Split, School of Medicine, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:673803

Žuvan L. Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017. [Master's thesis]. Split: University of Split, School of Medicine; 2018 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:673803

L. Žuvan, "Razlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.", Master's thesis, University of Split, School of Medicine, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:171:673803

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Metadata
TitleRazlike u kliničkim manifestacijama i komorbiditetima žena i muškaraca oboljelih od sistemskog eritemskog lupusa liječenih u KBC-u Split od 2007. do 2017.
Title (english)The differences between clinical manifestations and comorbidities between women and men with SLE treated in University Hospital of Split from January 2007 to Decembre 2017
AuthorLeona Žuvan
MentorDaniela Marasović Krstulović (mentor)
Committee memberDijana Perković (predsjednik povjerenstva)
Committee memberMislav Radić (član povjerenstva)
Committee memberJoško Božić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Internal medicine)
Split
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
CILJ ISTRAŽIVANJA: Cilj ovog istraživanja bio je ispitati razlike u kliničkim manifestacijama i komorbiditetima između muškaraca i žena oboljelih od SLE-a liječenih u KBC-u Split. METODE: Istraživanje je obuhvatilo 268 bolesnika s dijagnozom SLE-a u razdoblju od početka 2007. godine do kraja 2017. godine. Podatci su prikupljeni iz ambulanti, stacionara i dnevne bolnice Zavoda za reumatologiju i kliničku imunologiju Klinike za unutarnje bolesti Kliničkog bolničkog centra Split. Podatci su za vrijeme prikupljanja unošeni u programski paket Microsoft Office, odnosno u Microsoft Excel. Za statističku analizu korišten je paket SPSS 25 (IBM, New York, SAD). Koristili smo hi kvadrat test te univarijantnu i multivarijantnu logističku regresiju. REZULTATI: Od ukupno 268 ispitanika bilo je 26 (10 %) muškaraca i 242 (90 % ) žena. Medijan životne dobi ispitanika iznosio je 52 godine (min-maks: 22-88 god.; Q1-Q3: 41-62,75 god.). Hi kvadrat testom smo analizirali povezanost pojedinih kliničkih manifestacija i komorbiditeta sa spolom. Statistički značajnu poveznost smo dobili za Sjögrenov sindrom i pridružene neoplazme kod žena, a antifosfolipidni sindrom (APS) i vaskulitis kod muškaraca. S obzirom na medijan životne dobi podijelili smo svoje ispitanike u tri skupine. U najstarijoj dobnoj skupini >70 godina nije bilo muškaraca, stoga smo za povezanost dobi i pojednih kliničkih manifestacija isključili bolesnike >70 godina. Hi kvadrat testom dobili smo statistički značajnu povezanost izneđu mlađe dobne skupine i kožnih promjena te lupus nefritisa. Kod starijih je bolesnika statistička značajnost bila prisutna za dislipidemiju, hipertenziju, osteoporozu, gastritis i zahvaćenost srca. Multivarijantnom logističkom regresijom u kojoj su neovisne varijable bile dob i spol dobili smo statistički značajne rezulate. U žena je češća pojavnost Sjögrenova sindroma (P=0,04) i pridruženih neoplazmi (P=0,004), dok su u muškaraca učestaliji vaskulitis (P=0,014) i APS (P=0,03). ZAKLJUČCI: U našem istraživanju bolesnika sa SLE-om u žena su bili učestaliji Sjögrenov sindrom i pridružene neoplazme, a kod muškaraca vaskulitis i APS. Lupus nefritis i kožne promjene se javljaju češće u bolesnika mlađe životne dobi u oba spola. Kod starijih bolesnika češće su dislipidemija, hipertenzija, zahvaćenost srca, osteoporoza i gastritis. Za jasnije istraživanje ovog problema potrebno je istražiti puno veću populaciju bolesnika te ih pratiti značajno dulje vrijeme.
Abstract (english)
OBJECTIVES: The aim of this study was to determine the defferences between clinical manifestations and comorbidities in women and men with SLE treated in University Hospital of Split from January 2007 to Decembre 2017. METHODS: The study included 268 patients with SLE diagnosis from the beginning of 2007 to the end of 2017. The data were collected from outpatient clinics, stationers and daily hospital of the Department of Rheumatology and Clinical Immunology of the Clinic for Internal Diseases of University Hospital of Split. During the collection process, the data is included in the Microsoft Office program package, or in Microsoft Excel, a program designed to create a table of budgets. For statistical analysis, SPSS 25 was used. We used chi square test and multivariate logistic regression. RESULTS: Among 268 SLE patients, there were 26 (10%) males and 242 (90%) females. The median age of the patients was 52 years (min-max: 22-88 years; Q1-Q3: 41-62.75 years). We explored the association of individual clinical manifestations and comorbidities with gender with the chi square test. A statistically significant association was obtained for Sjögren's syndrome and associated neoplasms with female gender, and for antiphospholipid syndrome (APS) and vasculitis with male gender. According the median age we divided our respondents into three groups. In the oldest age group >70 years there were no males, so we excluded patients > 70 years. The chi square test showed statistically significant association between younger age and skin changes and lupus nephritis. In older patients, statistical significancant relation was found for dyslipidemia, hypertension, osteoporosis, gastritis and heart involvement. In multivariate logistic regression with the age and gender as independent variables, significantly higher frequency of Sjogren's syndrome (P = 0.04) and associated neoplasms (P = 0.004) were found in females, while vasculitis (P = 0.014) and APS (P = 0.003) were more frequent in males with SLE. CONCLUSION: Women with SLE are more frequently affected by Sjögren's syndrome and associated neoplasms, while men with SLE suffer more frequently of vasculitis and APS. Lupus nephritis and skin changes usually occur in both sexes in younger patients. In older patients dyslipidemia, hypertension, heart failure, osteoporosis and gastritis are more frequent than in younger patients with SLE. .
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:673803
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-27 13:21:22