Objectives: To determine the number of invasive candida infections in patients caused by, either the C. albicans or non-albicans Candida spp., throughout a three-year period of 2015.- 2017. in Intensive Care Unit of University Hospital of Split. The intent is also to show epidemiological and clinical characteristics of the invasive candidiasis as well as the type of pathogen, risk factors, accompanying diseases, prognosis and the possibility of treating the infection based on the results of the microbiological sensitivity test. Furthermore, the patients were divided into two groups with regard to the type of pathogen and statistically compared with regard to the risk factors and the occurrence of the disease. Study design: Retrospective observational study Participants and methods: A retrospective study was carried out at the Department of Anesthesiology, Reanimation and Intensive care of University Hospital of Split, involving 27 patients, 10 female and 17 males. All patients were registered by age, sex, type of pathogen causing the infection, advisable diagnosis, duration of treatment in the premises of Intensive Care Unit of University Hospital of Split, time spent on mechanical ventilation, surgical procedure and type of antibiotic therapy that directly preceded the evidence of infection and mortality. Results: Of the total of 27 patients, microbiological testing has found 22 (81 %) patients with non-albicans infections while in the remaining 5 (19 %) patients C. albicans infection was confirmed. Observing the association of sex with the development of infection, it is apparent that infection with Candida, irrespective of the type, was somewhat more common in male sex (62 %). In patients with infection with C. albicans, in all cases fungus were susceptible to 6 investigated antifungal drugs. In patients with non-albicans Candida spp. infection caspofungin or anidulafungin resistance was developed in 1 patient (4 %). There was no developed resistance for amphotericin B and micafungin usage. Voriconazole resistance was developed in 14 patients (63 %), while fluconazole resistance developed in as many as 20 patients (91 %). Patients infected with C. albicans were treated an average of 32.2 ± 21.3 days in Intensive Care Unit of University Hospital of Split, 17±12.1 days were on the mechanical ventilation, while patients with non-albicans Candida spp. were treated an average of 39.09±38.1 days, of which they spent 26.4±13.03 days on mechanical ventilation. All patients were subjected to some form of invasive monitoring; the most commonly used was central venous catheter. Concomitant antibiotic treatment was provided to all patients with C. albicans infection and 21 out of 22 patients with non-albicans Candid spp. infection were also subjected to antibiotic treatment. From the group with C. albicans infection 4 (80%) patients had history of surgical intervention, while in the second control group, 19 patients (86%) had the same data. During the study of all patients with C. albicans infection 1 (20%) died, while in group with non-albicans Candida spp. infection 7 (31%) patients died. Conclusion: This study showed a higher incidence of infections caused by non-albicans Candida spp. than C. albicans. Eighty-one percent of all forms of invasive candidiasis was caused by non-albicans Candida spp. of which approximately 90 % of fungus developed resistance to fluconazole, one of the most frequently used antifungal drugs. Only 7% of fungus developed resistance to drugs from the group of echinocandins used in this study. There is no statistically significant difference between the risk factors for the infection occurrence with C. albicans compared to non-albicans Candida spp.