| Abstract | Cilj istraživanja: Analizirati pojavnost Crohnove bolesti u Splitsko-dalmatinskoj županiji tijekom devetogodišnjeg razdoblja, te analizirati kliničke i epidemiološke čimbenike i njihove promjene tijekom spomenutog razdoblja.
Materijali i metode: Uzorak pacijenata obuhvaća sve pacijente s dijagnozom Crohnove bolesti starije od 18 godina, upisane u Registar za upalne bolesti crijeva Kliničkog odjela za gastroenterologiju i hepatologiju KBC Split od 2006. do 2014. godine. Provedeno istraživanje je bilo presječno retrospektivno. Za obradu podataka korišten je SPSS program.
Rezultati: Analizirano je ukupno 204 pacijenata, od kojih je bilo 116 muškaraca (56,9%) i 86 žena (43,1%). Prosječna dob svih bolesnika iznosila je 42,4±15,6 godina; za muškarce 40,2±13,8 godina, a za žene 45,3±17,4 godina, što je bila statistički značajna razlika (P=0,024). Dobna razdioba ukazala je na najveći broj ispitanika u mladim dobnim skupinama. Analiza obrazovne strukture ukazala je na najveći broj ispitanika sa srednjom razinom obrazovanja 137 (67,2%), a prema mjestu stanovanja najviše bolesnika, 92 (45,1%), bilo je iz gradskih područja. Najviše pacijenata, ukupno 156 slučajeva (76,5%), imalo je tešku kliničku sliku bolesti. Dob je bila statistički značajno povezana s težinom kliničke slike (P=0,038); U trenutku dijagnoze najviše pacijenata, njih ukupno 86 (42,1 %), je imalo bolest leokolona. Prilikom dijagnosticiranja bolesti većini pacijenata je napravljena patohistološka analiza (83,8%) i totalna kolonoskopija (70,6%), a terminalna ileoskopija je urađena u 28,4%. Pacijenti su najčešće liječeni kortikosteroidima (79,9%). Kirurški je liječena otprilike trećina bolesnika (34,4%).
Zaključak: Brojna istraživanja ukazuju na porast pojavnosti Crohnove bolesti. Ovo je prvo takvo istraživanje napravljeno za Splitsko- dalmatinsku županiju i razlika u učestalosti pojave bolesti kroz praćeni period nije pokazala statistički značajan trend. Analiza epidemioloških i kliničkih karakteristika pacijenata s Crohnovom bolesti je bitna i trebalo bi je nastaviti kako bismo dobili što bolji uvid u čimbenike razvoja bolesti i ovisnosti tih čimbenika o težini kliničke slike. Na taj način bismo mogli omogućiti bolji terapijski pristup u liječenju ove, za sada, neizlječive bolesti. |
| Abstract (english) | Aims: To analyze the incidence of Crohn's disease in Split-Dalmatia County during the nine year period, and to analyze clinical and epidemiological factors and their changes in the mentioned period.
Materials and methods: The sample of patients includes all patients with Crohn's disease diagnosis, that are older than 18 and registered in the inflamatory bowel disease register of Department of Gastroenterology and Hepatology of University Hospital Split from 2006 till 2014. Conducted research was retrospective. SPSS software was used for data analysis.
Results: 204 patients were analyzed, from which there were 116 men (56,9%) and 86 women (43,1%). The average age of all patients was 42,4±15,6 years; the average age for men 40,2±13,8 was and for women 45,3±17,4, which was a statistically significant difference (P=0,024). Age distribution showed that most of the patients were in younger age groups. Education analysis showed most of the patients had a secondary level of education and place of residence analysis showed that most of the patients, 92 of them (45,1%), lived in urban areas. The most of the patients, a total of 156 cases (76,5%), had severe stage of the disease. Age was statistically correlated with the severity of the disease (P=0,038); At the moment of diagnosis most of the patients, 86 of them (42,1%), had ileocolonic disease. During disease diagnostics most of the patients have had pathohistological analysis (83,8%) and total colonoscopy (70,6%). Patients were mostly treated with corticosteroids (79,9%). Around one third of the patients was surgically treated.
Conclusion: Many studies have shown increasment of the incidence of Crohn's disease. This is the first study of that kind made for Split-Dalmatia County and there was no statistically significant incidence of trend in observed period. Analysis of epidemiological and clinical characteristics of patients with Crohn's disease is important and should be continued in order to get a better insight into the factors of disease development and their dependence on severity of disease. That way, it would be possible to ensure better therapy approach in treatment of this, at the moment, incurable disease. |
