prikaz prve stranice dokumenta Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib
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master's thesis
Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib
2019. urn:nbn:hr:171:229121
Siebers, Nys
University of Split
School of Medicine
Hystology and embryology

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Siebers, N. (2019). Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:229121

Siebers, Nys. "Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:229121

Siebers, Nys. "Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:229121

Siebers, N. (2019). 'Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib', Master's thesis, University of Split, School of Medicine, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:229121

Siebers N. Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib [Master's thesis]. Split: University of Split, School of Medicine; 2019 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:171:229121

N. Siebers, "Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib", Master's thesis, University of Split, School of Medicine, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:171:229121

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Metadata
TitleChanges of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib
Title (croatian)Promjene intenziteta boli u različitim vremenima praćenja u randomiziranim kontroliranim pokusima o celekoksibu za osteoartritis
AuthorNys Siebers
MentorLivia Puljak (mentor)
Committee memberDamir Sapunar (predsjednik povjerenstva)
Committee memberIvana Mudnić (član povjerenstva)
Committee memberRenata Pecotić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Hystology and embryology)
Split
Defense date and country2019-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract
Objectives: The aim of this Thesis was to conduct comprehensive analysis of efficacy data for pain in randomized controlled trial RCTs about Celecoxib in osteoarthritis (OA). The ultimate purpose of this study is to improve long-term management of pain for patients suffering from OA by guiding clinical decision making, and to create evidence that will inform design of future RCTs about OA. Material and Methods: This was a methodological study in which publicly available data from RCTs were analyzed. RCTs analyzing the effects of 200 mg celecoxib vs. placebo on pain intensity with the Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score were included. Random effect meta-analysis was used for different pain outcome measures and different follow-up times. Standardized mean differences were used to report the data. Results: We found a decreasing trend of a numerical indicator for efficacy of celecoxib for treatment of pain in RCTs comparing Celecoxib 200 mg to Placebo and reported pain results with the VAS and WOMAC scale. Standardized mean differences remained relatively constant with VAS and WOMAC over most follow-up times. The later follow-up times showed a decreased SMD for VAS at 13 weeks as well as for WOMAC with 24 weeks. Conclusion: Our data indicates that efficacy of celecoxib 200 mg could decrease over longer follow-up times. Future trials should include assessment at longer follow-up times for adequate assessment of efficacy and safety of celecoxib.
Abstract (croatian)
Ciljevi: Cilj ove disertacije bio je provesti detaljnu analizu o ishodima koji opisuju intenzitet boli u randomiziranim kontroliranim pokusima (engl. randomized controlled trials; RCTs) o celekoksibu za osteoartritis (OA). Konačni cilj je dati nove informacije za praksu i omogućiti ustroj boljih RCT-ova u budućnosti. Metode: Provedeno je metodološko istraživanje u kojem su analizirani javno dostupni podatci iz RCT-ova. Uključeni su RCT-ovi koji su analizirali djelotvornost i sigurnost celekoksiba 200 mg u usporedbi s placebom. Intenzitet boli je analiziran vizualno-analognom ljestvicom (engl. Visual-Analog Scale; VAS) i WOMAC ljestvicom (engl. Western Ontario and McMaster Universities Osteoarthritis Index). Provedena je meta-analiza nasumičnih učinaka (engl. random effect meta-analysis) kako bi se analizirao zbirni učinak za različite mjere ishoda u različitim vremenima praćenja. Standardizirane srednje razlike (engl. standardized mean differences; SMD) su korištene za prikaz podataka. Rezultati: Uočen je trend smanjenja SMD za djelotvornost celekoksiba za liječenje OA prema mjernim instrumentima VAS i WOMAC u kasnijim vremenima praćenja. Pokusi koji su koristili ljestvicu VAS trajali su najviše 13 tjedana, a pokusi koji su koristili ljestvicu WOMAC najviše 24 tjedna. Zaključak: Dobiveni podatci ukazuju da bi djelotvornost celekoksiba za liječenje boli u OA mogla biti manja s duljim vremenom primjene lijeka. Novi klinički pokusi trebali bi uključiti dulje vrijeme praćenja kako bi se dobili odgovarajući podatci iz istraživanja o dugoročnoj djelotvornosti i sigurnosti celekoksiba u OA koji je kronična bolest.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:229121
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-17 12:51:45