prikaz prve stranice dokumenta Assessment of adverse drug reaction reports
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master's thesis
Assessment of adverse drug reaction reports
metformin and metformin fixed drug combinations
2019. urn:nbn:hr:171:061729
Larsen Matić, Ina
University of Split
School of Medicine
Pathophysiology

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Larsen Matić, I. (2019). Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:061729

Larsen Matić, Ina. "Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:061729

Larsen Matić, Ina. "Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:061729

Larsen Matić, I. (2019). 'Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations', Master's thesis, University of Split, School of Medicine, accessed 01 June 2023, https://urn.nsk.hr/urn:nbn:hr:171:061729

Larsen Matić I. Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations [Master's thesis]. Split: University of Split, School of Medicine; 2019 [cited 2023 June 01] Available at: https://urn.nsk.hr/urn:nbn:hr:171:061729

I. Larsen Matić, "Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations", Master's thesis, University of Split, School of Medicine, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:171:061729

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Metadata
TitleAssessment of adverse drug reaction reports : metformin and metformin fixed drug combinations
Title (croatian)Pregled prijava sumnji na nuspojave lijekova : metformin i metformin u fiksnim kombinacijama
AuthorIna Larsen Matić
MentorJoško Božić (mentor)
Committee memberDarko Modun (predsjednik povjerenstva)
Committee memberRenata Pecotić (član povjerenstva)
Committee memberIvana Mudnić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathophysiology)
Split
Defense date and country2019-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
Objectives: The aim of the present study was to compare adverse drug reaction reports of metformin and metformin in fixed combination in Croatia from 2007 to 2018. Materials and Methods: The data of adverse drug reaction reports received from 1 January 2007 to 31 December 2018 was analyzed in this retrospective study. Metformin reports were categorized into two main groups: single‐drug formulations and fixed‐dose combinations of drugs. The data of the year of the adverse drug reaction report, reporter qualification, patient age and gender, adverse drug reaction seriousness and other medication in therapy was included. Results: During the examined period the number of the metformin adverse drug reactions reports was 377 (70.3%) and metformin in combinations had 159 (29.7%) reported adverse drug reactions. Overall, this accounts for 536 adverse drug reaction reports included in this study. Majority of all the reports were provided by physicians. Female consumers reported a largest proportion of adverse drug reactions when compared to male consumers. Most of the reports were obtained by elderly, and included concomitant drug in therapy, other than suspected metformin or metformin in combination. Most commonly reported drug combination was metformin and vildagliptin, which were included in 55 of the reports. Majority of the reports, 87.1 %, included adverse drug reaction classified as non-serious and lactic acidosis was reported in 1% of the cases. Conclusion: Metformin was more frequently reported than metformin in combinations during the examined period. However, as the market of hypoglycemic drug combinations will probably rise in the future, the education of all the interested parties should be proposed in order to monitor safety of newly introduced drugs.
Abstract (croatian)
Ciljevi: Usporediti prijave sumnji na nuspojave lijekova metformina i metformina u fiksnim kombinacijama u Republici Hrvatskoj u razdoblju od 2007. do 2018. Materijali i metode: Podatci o prijavama sumnji na nuspojave lijekova zaprimljeni od 1. siječnja 2007. do 31. prosinca 2018. analizirani su u ovom retrospektivnom istraživanju. Prijave metformina podijeljene su u dvije skupine: metformin i metformin u fiksnim kombinacijama. Podatci o godini prijave, kvalifikaciji prijavitelja, dobi i spolu pacijenta, ozbiljnosti nuspojave i broju ostalih lijekova u terapiji su uključeni u ovo istraživanje. Rezultati: Tijekom ispitnog razdoblja broj sumnji na nuspojave metformina iznosio je 377 (70,3%), a metformin u kombinacijama imao je 159 (29,7%) prijavljenih sumnji na nuspojave. Sveukupno, to čini 536 prijavljenih sumnji na nuspojavu lijekova koje su uključene u ovo istraživanje. Liječnici su prijavili najviše sumnji na nuspojave ovih lijekova. Ženski pacijenti prijavili su više sumnji na nuspojavu lijekova u usporedbi s muškarcima. Većina zaprimjlenih sumnji uključivala je pacijente starije životne dobi koji su koristili druge lijekove u terapiji, izuzev metformina ili metformina u kombinacijama. Najčešće prijavljena kombinacija lijekova bila je kombinacija metformina i vildagliptina za koju je zaprimljeno 55 prijava. Većina prijava, 87,1 %, nije uključivala kriterije ozbiljnosti te nisu kategorizirane kao ozbiljne nuspojave. Laktička acidoza prijavljena je u 1% svih slučajeva sumnji na nuspojave. Zaključak: U promatranom razdoblju je prijavljen veći broj sumnji na nuspojave lijekova za metformin, nego za fiksne kombinacije metformina. Međutim, kako će u budućnosti rasti tržište hipoglikemika potrebna je edukacija svih dionika zdravstvenog sustava kako bi se poboljšalo praćenje sigurnosti novih lijekova.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:061729
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-24 10:44:43