| Abstract | Cilj istraživanja: Cilj istraživanja je bio utvrditi kvalitativne i kvantitativne potrebe za transfuzijskim liječenjem u bolesnika oboljelih od MDS-a s obzirom na parametre spola, dobi, MDS klasifikacije, godinu početne dijagnoze, trajanje bolesti, prosječne vrijednosti eritrocita, trombocita i hemoglobina, broj primljenih transfuzija eritrocita i trombocita za vrijeme hospitalizacije te broj smrtnih ishoda.
Metode: U ovom retrospektivnom istraživanju obuhvaćena su 63 bolesnika s ukupno 119 hospitalizacija na Zavodu za hematologiju Klinike za unutarnje bolesti KBC-a Split u razdoblju od 1. siječnja 2013. do 31. prosinca 2014. godine. Podaci su prikupljeni popisnom metodom iz arhive Klinike za unutarnje bolesti te Zavoda za transfuzijsku medicinu probirom otpusnih pisama te usporedbom s bolničkim kartonima.
Rezultati: Među 63 ispitanika je bilo 26 žena (41,27%) i 37 muškaraca (58,73%), prosječne životne dobi od 74 godine. Tijekom istraživanja je preminulo 13 ispitanika (20,63%), a udio smrtnih ishoda prevladava kod muškaraca (61,54% prema 38,46%). Najčešće dijagnosticirana podvrsta bolesti je MDS neklasificirani (32%), a najveći broj smrtnih ishoda se dogodio pod dijagnozom AML transformacije (38,5%). Najveći broj ispitanika je bio hospitaliziran samo jednom (61,9%). U 75,63% hospitalizacija su bile potrebne transfuzije eritrocita, a u 47,05% transfuzije trombocita. Prosječni broj primljenih eritrocitnih transfuzija kod žena iznosi 1,95 doza, a kod muškaraca 1,54 doze. Prosječni broj primljenih trombocitnih transfuzija iznosi 2,37 doza.
Zaključak: MDS je klinički heterogena bolest starije životne dobi koja zahtijeva višestruka bolnička liječenja, a češće pogađa muškarce. Liječenjem se nastoji spriječiti ili barem odgoditi pojava dvaju neminovnih ishoda – leukemijske transformacije i ovisnosti o transfuzijskom liječenju. Broj ispitanika je obrnuto proporcionalan broju hospitalizacija po ispitaniku. Razlog tome je postojanje dnevne bolnice kroz koju se većina bolesnika uspješno liječi, umanjujući potrebe za hospitalizacijom. Prosječni broj svih primljenih transfuzija se povećava s učestalošću bolničkog liječenja. U 3/4 hospitalizacija su bile potrebne transfuzije eritrocita, a u gotovo pola slučajeva transfuzije trombocita. |
| Abstract (english) | Objectives: The aim of this study was to determine qualitative and quantitative demands of transfusional therapy in patients with myelodisplastic syndrome with regards to age, sex, MDS classification, year of initial diagnosis, duration of the disease, red and platelet count, haemoglobin levels, red and platelet count, number of administered RGB, platelet and fresh frozen plasma transfusions and finally the number of deceased patients
Methods: This retrospective study encompassed 63 individual patients (119 due to recurring hospitalizations) with MDS who were admitted and treated at the Department of Hematology, University Hospital Split in the period from January 1st 2013 to December 31st 2014. The data was gathered using hospital records from the Department's archives for case identification and cross-referencing them with data from the Departmen of Transfusion Medicine.
Results: The study encompassed 63 subjects consisting of 26 women (41,27%) and 37 men (58,73) with the average age of 74. During the research 13 subjects (20,63%) passed away with the ratio of mortality being more dominant in men (61,54% to 38,46%). The most diagnosed subgroup was MDS unclassified (32%) and the majority of deaths occured under the diagnosis of AML transformation (38,5%). The majority of subjects required only one hospitalization (61,9%). Erythrocyte and thrombocyte transfusions were required in 75,63% and 47,05% cases, respectively. The average number of administered erythrocyte transfusions for women and men was 1,95 and 1,54 doses, respectively. The average number of thrombocyte transfusions was 2,37 doses.
Conclusion: MSD is a clinically heterogenic disease of the elderly which requires multiple hospitalizations, occuring more often in men. The main goal of treatment is to prevent or to postpone the occurance of two inevitable outcomes – leukemic transformation and transfusion dependence. The number of patients is inversely proportional to the number of hospitalizations per subject with the main reason being the existance of the daily hospital through which the majority of patients is treated, diminishing the need for hospital admittance. The average number of all administered transfusions increases with the frequency of hospitalizations. 3/4 of cases required erythrocyte transfusions and nearly half of them required thrombocyte transfusions. |
