The aim of the study is to gain insight into the level of compliance of patients who have been treated with antihypertensives over a period of ten years and to determine factors influencing compliance. The study included 58 patients. The examination was performed by monitoring the prescribing of the therapy in family medicine practice by means of the proportion of days covered and by using the questionnaire method. The results of this study show a statistically significant increase in compliance levels in the observed period of ten years of treatment (p <0.001).This research has established that patients' compliance with hypertension therapy is increasing over the years, and that increased compliance does not depend on complications of the hypertension.The proportion of collaborative patients at the end of the ten-year period was 75.86% using the PDC method and 72.41% using questionairre. Although we used different methods, they show approximately the same proportion of adherent patients. The established proportion of adherent patients is consistent with the results of previous studies. Among the factors examined, a positive correlation with compliance was foun with higher level of education, the existence of dyslipidemia as a follow-up disease, and the total number of visits to the clinic due to hypertension. Other factors have not shown any significant influence on compliance despite the fact that earlier studies have shown the influence of the same factors on the degree of adherence. It is necessary to extend the current research to a greater number of patients and clinics to make the results more credible.