The aim of the research: To determine whether there is an association between depression and increased cardiovascular risk, to determine whether cardiovascular risk is higher in patients with depression than in patients with bladder stones. Patients and methods: The data were collected from the medical records from the one family physician’s office in Split. A total of 68 patients were enrolled, 36 of whom were depressed (intervention group) and 37 with urolithiasis (control group), who were first diagnosed with one of these two diseases between 2012 and 2017. Each patient was followed for an equal period of time (365 days) from the diagnosis of one of these two diseases. Statistical analysis was performed in the statistical program STATISTICA 12. Results: There was no statistically significant difference for the analyzed parameters (cholesterol, HDL, systolic pressure, diastolic pressure, pressure treatment, smoking, and diabetes) between the intervention and control groups at the beginning and end of the study. No significant difference was found in the analysis in the level of cardiovascular risk between the intervention and control groups (Z = 1,40; p = 0,161). The increase in the level of cardiovascular risk reached statistical significance in both the intervention group (Z = 5,00; p <0,001) and the control group (Z = 5,00; p <0,001). In the intervention group was observed significantly more visits to the physician, both due to worsening (Z = 2,29; p = 0,022) and due to control (t = 2,26; p = 0,022) compared to the control group. Conclusion: The level of cardiovascular risk is not higher among patients with depression than among patients with urolithiasis. These two test groups had similar values for all the parameters tested. In patients with depression, there was a significantly higher number of doctor visits compared to patients with urolithiasis.