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master's thesis
PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE
2020. urn:nbn:hr:171:013947
Marđetko, Jure
University of Split
School of Medicine
Infectology

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Marđetko, J. (2020). PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:013947

Marđetko, Jure. "PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:013947

Marđetko, Jure. "PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:013947

Marđetko, J. (2020). 'PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE', Master's thesis, University of Split, School of Medicine, accessed 03 June 2023, https://urn.nsk.hr/urn:nbn:hr:171:013947

Marđetko J. PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2023 June 03] Available at: https://urn.nsk.hr/urn:nbn:hr:171:013947

J. Marđetko, "PRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:013947

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Metadata
TitlePRAĆENJE CLOSTRIDIUM DIFFICILE INFEKCIJA U OPĆOJ BOLNICI ZADAR TIJEKOM RAZDOBLJA 2016. – 2019. GODINE
Title (english)SURVEILLANCE OF CLOSTRIDIUM DIFFICILE INFECTIONS IN ZADAR GENERAL HOSPITAL FROM JUNE 1, 2016 TO DECEMBER 31, 2019
AuthorJure Marđetko
MentorBoris Dželalija (mentor)
Committee memberIvana Goić Barišić (predsjednik povjerenstva)
Committee memberIvo Ivić (član povjerenstva)
Committee memberRenata Pecotić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Infectology)
Split
Defense date and country2020, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Cilj istraživanja: Cilj je ovog istraživanja prikazati učestalost i epidemiološke osobitosti Clostridium difficile infekcija te demografska obilježja oboljelih u Općoj bolnici Zadar tijekom razdoblja 1. 6. 2016. – 31. 12. 2019. godine, kao i ustanoviti povećavaju li određeni čimbenici učestalost smrtnog ishoda među oboljelima. Materijali i metode: Provedeno je retrospektivno kohortno istraživanje u kojem su sudjelovali svi bolesnici liječeni zbog Clostridium difficile infekcije u Općoj bolnici Zadar od 1. lipnja 2016. do 31. prosinca 2019. godine. Kao instrument istraživanja koristio se standardizirani obrazac Formular C iz Protokola europskog praćenja infekcija izazvanih bakterijom Clostridium difficile, verzija 2.2 kojim su zabilježeni osobni podatci ispitanika, kao i relevantni podatci vezani uz samu CDI, a statistički značajna razlika između određenih kategorija ispitanika ispitana je hi-kvadrat testom na razini značajnosti P < 0.05. Rezultati: Od 1. lipnja 2016. – 31. prosinca 2019. godine u Općoj bolnici Zadar zabilježeno je ukupno 114 CDI, od čega 57% u muškaraca te 43% u žena. Od ukupnog broja slučajeva, 89% činile su CDI povezane sa zdravstvenom skrbi, 10% izvanbolničke CDI, dok je samo jedan slučaj bio nepoznatog podrijetla. Prosječna vrijednost McCabe skora svih ispitanika iznosila je 1.76, od čega je gotovo polovica ispitanika imala McCabe skor 1. Gledajući samo slučajeve sa smrtnim ishodom, proječna vrijednost McCabe skora 24 preminula ispitanika iznosila 2.83, od čega je 83% imalo McCabe skor 3. Čak 74% svih ispitanika hospitalizirano je ili je boravilo u ustanovi za dugotrajnu skrb unutar tri mjeseca prije nastupa CDI, međutim, nije se utvrdila povezanost istog s konačnim ishodom liječenja. Rekurentne epizode činile su 11% svih CDI, a ishod liječenja istih nije se značajno razlikovao u odnosu na ishod svih ostalih slučajeva CDI. Zaključak: CDI povezane sa zdravstvenom skrbi značajno su učestalije od izvanbolničkih CDI. Bolesnici u kojih je zabilježen McCabe skor 3 značajno češće završavaju smrtnim ishodom u odnosu na bolesnike u kojih McCabe skor iznosi 2. Stopa smrtnosti bolesnika s rekurentnom epizodom CDI ne razlikuje se značajno od stope smrtnosti bolesnika u kojih se ne radi o rekurentnoj infekciji.
Abstract (english)
Objectives: The aim of this study is to estimate the incidence and the epidemiological characteristics of Clostridium difficile infections and demographic characteristics of patients with CDI in Zadar General Hospital from June 1, 2016 to December 31, 2019, as well as to establish the effect of certain factors on the frequency of a fatal outcome. Patients and Methods: We conducted a retrospective cohort study involving all patients treated for Clostridium difficile infection in the Zadar General Hospital from June 1, 2016 to December 31, 2019. We used a standardized Form C from the Surveillance protocol version 2.2. of the European surveillance of Clostridium difficile infection as a research instrument to record the personal data of the subjects, as well as relevant data related to CDI. We used chi-square test at the significance level P < 0.05 in order to establish a statistically significant difference between certain categories of subjects. Results: From June 1, 2016 to December 31, 2019, a total of 114 Clostridium difficile infections were recorded at the Zadar General Hospital, of which 57% in men and 43% in women. 89% were healthcare-associated CDI and 10% were community-associated CDI, while only one case was of unknown association. The average McCabe score of all subjects was 1.76, of which almost half had McCabe score 1. On the other hand, the average McCabe score of all 24 subjects with fatal outcome was 2.83, of which 83% had McCabe score 3. 74% of all subjects were hospitalized or stayed in a long-term care facility within three months before the onset of CDI. However, its association with the final outcome of treatment was not established. Recurrent episodes accounted for 11% of all CDI cases, and the treatment outcome of those did not differ significantly from the outcome of other CDI cases. Conclusion: Healthcare-associated CDIs are more common than community-associated CDIs. The proportion of deceased subjects with McCabe score 3 was significantly higher than the proportion of deceased subjects with McCabe score 2. Recurrent Clostridium difficile infection was not associated with increased mortality.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:013947
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-07-24 12:24:48