| Abstract | Ciljevi: Utvrditi karakteristike invazivnih karcinoma dojke dijagnosticiranih u KBC-u Split tijekom 2019. godine te analizirati osjetljivost citologije i iglene biopsije u dijagnostici malignih tumora dojke.
Ispitanici i metode: Retrospektivno istraživanje provedeno je na Kliničkom zavodu za patologiju, sudsku medicinu i citologiju KBC-a Split. U studiju su uključena 334 bolesnika s dijagnosticiranim invazivnim karcinom dojke u 2019. godini, dok su u pojedine analize bolesnici uključeni ovisno o zabilježenosti promatrane karakteristike. Uvidom u medicinsku dokumentaciju prikupljeni su klinički podatci, podatci o citološkom nalazu te patohistološkim karakteristikama karcinoma.
Rezultati: U KBC-u Split su tijekom 2019. godine dijagnosticirana 334 bolesnika s invazivnim karcinomom dojke. Među oboljelima je bilo 98,8% žena. Medijan dobi bolesnika je iznosio 63 godine, a medijan veličine tumora na operativnom materijalu 15 mm. Po fokalnosti, 77,08% analiziranih tumora je bilo solitarno, a najčešća lokalizacija karcinoma bio GLK lijeve dojke. Luminalni B je bio najzastupljeniji imunofenotip (48,6%), dok je prevladavajući histološki tip bio invazivni karcinom dojke nespecijalnog tipa (72,73%). Limfni čvorovi aksile nisu bili pozitivni u 71,43% bolesnika. Uočena je statistički značajna povezanost fokalnosti i histološkog tipa karcinoma (P=0,012) te imunofenotskih kategorija i histološkog gradusa tumora (P<0,01). Nije utvrđena korelacija veličine tumora s dobi bolesnika (P=0,383), ali je pronađena statistički značajna povezanost medijana dobi bolesnika s imunofenotipom tumora (P=0,025). Statistički je značajna povezanost vrste operacije i medijana slobodnog ruba (P<0,01). Osjetljivost citološke dijagnostike je iznosila 96,43%, a iglene biopsije 98,58%.
Zaključak: Među invazivnim karcinoma dojke dijagnosticiranima u KBC-u Split tijekom 2019. godine, učestaliji su solitarni tumori smješteni u GLK lijeve dojke. Najzastupljeniji histološki tip je invazivni karcinom NST, dok je po imunofenotipu najzastupljeniji luminalni B podtip. HER2 pozitivni tumori češći su u mlađoj životnoj dobi. Citološka dijagnostika i iglena biopsija su visoko osjetljive pretrage u dijagnostici karcinoma dojke. |
| Abstract (english) | Objectives: The main purpose of this study was to determine the characteristics of invasive breast cancers diagnosed at the University Hospital of Split during 2019. The second aim was to analyze the sensitivity of FNAC and CNB in the detection of breast malignancies.
Subjects and methods: A retrospective study was conducted at the Clinical Department of Pathology, Forensic Medicine and Cytology of the University Hospital of Split. This study included 334 patients with diagnoses of invasive breast cancer in 2019, while in some analyzes patients were included depending on the observed characteristics. Clinical data, cytological and pathohistological characteristics of cancer were collected by inspecting medical documentation.
Results: In 2019, 334 patients with invasive breast cancer were diagnosed at the University Hospital of Split. Among the patients, 98.8% were women. The median age of the patient was 63 years, and the median tumor size on the operative material was 15 mm. By focality, 77.08% of the analyzed tumours were solitary,and the most common localization of the cancer was the upper lateral quadrant of the left breast. Luminal B was the most common immunophenotype (48.6%), while the predominant histological type was invasive breast cancer of the nonspecial type (72.73%). Axillary lymph nodes were unaffected by cancer in 71.43% of patients. There was a statistically significant correlation between focality and histological type of cancer (P=0.012), and immunophenotypic categories and histological grade of the tumour (P<0.01). No correlation was found between tumour size and patients age (P=0.383), but a statistically significant association of the median age of patients with tumour immunophenotype was found (P=0.025). There was a statistically significant correlation between the type of surgery and the median of free edge (P<0.01). The sensitivity of FNAC was 96.43%, and CNB 98.58%.
Conclusion: Among invasive breast cancers diagnosed at University Hospital of Split during 2019, more common are solitary tumours located in the upper lateral quadrant of left breast. The most common histological type is invasive NST carcinoma, while the most common immunophenotype is the luminal B subtype. FNAC and CNB are highly sensitive tests in the detection of breast malignancies. |
