Purpose: To examine the immunohistochemical expression of the EGF growth factor, the transcription factor of HIF-1α in the VTB, EVTB and DS of term placentae from PE pregnancies and term placentae from orderly pregnancies, and to compare the results. To examine the proliferation index in the VTB, EVTB and DS of PE term placentae and to compare them to a healthy control group. Materials and methods: The examined group consists of 29 placentae from third trimester singleton pregnancies with a complicated PE and 19 term placentae from orderly pregnancies as a control group. The PE clinical diagnosis was set based on strict criteria for arterial hypertension in previously normotensive women and proteinuria. The exclusion criteria included the prior existence of arterial hypertension, kidney disease, as well as vascular disease and a diagnosed HELLP syndrome. The EGF, EGFR and HIF-1α expression was determined by the immunohistochemical method through the usage of specific antibodies. The proliferation activity was determined separately for DS, EVT and EVTB through the use of the Ki-67 antigen. The immunohistochemical staining with the CK7 antibody enabled the differentiation between DS and EVTB. Results: No statistically significant difference in the immunohistochemical expression of the EGF and EGFR was found between the PE term placentae and orderly term placentae of the control group. The HIF-1α immunohistochemical expression is statistically significantly higher in PE term placentae in relation to the orderly term placentae of the control group. The proliferation index is significantly higher in DS and EVTB in placentae from PE pregnancies in relation to the orderly term placentae of the control group. Although the proliferation index was higher in DS in relation to EVTB in both groups, that difference did not prove to be statistically significant. Conclusion: The immunohistochemical expression of the EGF growth factor and the EGF receptor did not differ between the PE placentae and the control term placentae due to the possible loss of role of this growth factor towards the end of the pregnancy. Because there are four receptors and fourteen ligands, and at least three signal pathways through which the aforementioned perform their activity, it is possible that precisely other ligands, such as HBEGF, affect the incidence of PE in term placentae more. 40 The immunohistochemical expression of the HIF-1α transcription growth factor was higher in all segments of the PE placentae compared to the control group placentae. By examining the immunohistochemical expression of the HIF-1α factor in DS, we have proven that the mother’s portion of the placenta exhibits the same response to hypoxia as the fetal does. As the inflammatory cytokines, antibodies that are high in PE can lead to a higher expression of HIF1α independently from hypoxia, the explanation of the study results has to take into consideration the listed paracrine influences as well. An early accelerated proliferation of DS and EVTB is necessary for the proper growth and development of the placenta. The nearly triple proliferation index in DS and EVTB of PE placentae in relation to the control term placentae might represent a compensatory mechanism as a consequence of inadequate proliferation and differentiation in the early stages of the pregnancy.