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Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels
International Journal of Molecular Sciences, 23 (2022), 4; 1181663. https://doi.org/10.3390/ijms23042173
Pleić, Nikolina; Babić Leko, Mirjana; Gunjača, Ivana; Boutin, Thibaud; Torlak, Vesela; Matana, Antonela; Punda, Ante; Polašek, Ozren; Hayward, Caroline; Zemunik, Tatijana

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Pleić, N., Babić Leko, M., Gunjača, I., Boutin, T., Torlak, V., Matana, A. ... Zemunik, T. (2022). Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels. International Journal of Molecular Sciences, 23. (4). doi: 10.3390/ijms23042173

Pleić, Nikolina, et al. "Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels." International Journal of Molecular Sciences, vol. 23, br. 4, 2022. https://doi.org/10.3390/ijms23042173

Pleić, Nikolina, Mirjana Babić Leko, Ivana Gunjača, Thibaud Boutin, Vesela Torlak, Antonela Matana, Ante Punda, Ozren Polašek, Caroline Hayward i Tatijana Zemunik. "Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels." International Journal of Molecular Sciences 23, br. 4 (2022). https://doi.org/10.3390/ijms23042173

Pleić, N., et al. (2022) 'Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels', International Journal of Molecular Sciences, 23(4). doi: 10.3390/ijms23042173

Pleić N, Babić Leko M, Gunjača I, Boutin T, Torlak V, Matana A, i sur.. Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels. International Journal of Molecular Sciences [Internet]. 2022. [pristupljeno 13.04.2024.];23(4). doi: 10.3390/ijms23042173

N. Pleić, et al., "Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels", International Journal of Molecular Sciences, vol. 23, br. 4, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:171:272227. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:171:272227
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Podaci o radu
Naslov (engleski)Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels
AutorNikolina Pleić
MBZ: 40552932384
AutorMirjana Babić Leko
MBZ: 42858428090
AutorIvana Gunjača
MBZ: 16560336337
AutorThibaud Boutin
AutorVesela Torlak
MBZ: 73750438939
AutorAntonela Matana
MBZ: 21209748989
AutorAnte Punda
MBZ: 03985407884
AutorOzren Polašek
MBZ: 75588813581
AutorCaroline Hayward
AutorTatijana Zemunik
MBZ: 68056150276
Autorova ustanova(Klinički bolnički centar Split)
Autorova ustanovaSveučilište u Splitu
Medicinski fakultet
(Medicinska biologija)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Thyroglobulin (Tg) is an iodoglycoprotein produced by thyroid follicular cells which acts as an essential substrate for thyroid hormone synthesis. To date, only one genome-wide association study (GWAS) of plasma Tg levels has been performed by our research group. Utilizing recent advancements in computation and modeling, we apply a Bayesian approach to the probabilistic inference of the genetic architecture of Tg. We fitted a Bayesian sparse linear mixed model (BSLMM) and a frequentist linear mixed model (LMM) of 7, 289, 083 variants in 1096 healthy European-ancestry participants of the Croatian Biobank. Meta- analysis with two independent cohorts (total n = 2109) identified 83 genome-wide significant single nucleotide polymorphisms (SNPs) within the ST6GAL1 gene (p<5×10−8). BSLMM revealed additional association signals on chromosomes 1, 8, 10, and 14. For ST6GAL1 and the newly uncovered genes, we provide physiological and pathophysiological explanations of how their expression could be associated with variations in plasma Tg levels. We found that the SNP-heritability of Tg is 17% and that 52% of this variation is due to a small number of 16 variants that have a major effect on Tg levels. Our results suggest that the genetic architecture of plasma Tg is not polygenic, but influenced by a few genes with major effects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 4, 1181663
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23042173
URN:NBNurn:nbn:hr:171:272227
Datum objave publikacije2022
ProjektŠifra: 2593
Naziv (hrvatski): Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi
Pravna nadležnost: Hrvatska
Financijer: HRZZ
URL dokumentahttp://bib.irb.hr/1181663
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-08 12:38:47