Objectives: To evaluate the quality of life of patients with autoimmune hypothyroidism and compare if there are any differences between smokers and non-smokers Materials and methods: A retrospective case-control study was done in the department of endocrinology of the Regiomed hospital in Coburg. In the Medical Care Center (MCC) of the 61 patients selected, 52 were non-smokers, and 9 were smokers. Patients’ data was assessed by the ThyPRO-39 questionnaire, an anamnestic questionnaire, blood tests, and ultrasound examination of the thyroid gland. Results: There was no statistically significant difference in the quality of life between smokers and non-smokers (P=0.425). There was no statistically significant difference between the autoantibody titer of Anti-TPO (P=0.463) and Anti-Tg (P=0.421) between smokers and non-smokers. There was no statistically significant difference between fT3 (P=0.568) & fT4 levels(P=0.262) between smokers and non-smokers. TSH was statistically significantly lower in the smoker group compared to the non-smoker group (P=0.015). The quality-of-life score correlates positively with fT4 (r=0.572, P=0.003). In the boxplot the parameters (TV, TSH, fT3, Anti-TPO, Anti-Tg) did not differ between the quartiles of the score of the quality of life. However, fT4 differs between the quartiles of the score of the quality of life. The quality-of-life score did not differ between the quartiles of Anti-TPO. Anti-TPO positively correlates with “Impaired Social Life (r=0.641, P=0.007). Conclusion: Except TSH, there was no statistically significant difference between the smokers and non-smoker regarding the quality of life. The quality-of-life score correlates positively with fT4. Anti-TPO positively correlates with “Impaired Social Life”