Cilj istraživanja: Cilj je rada istražiti učestalost i klinička obilježja primarnog i sekundarnog Sjögrenova sindroma u Dalmaciji, te prisutnost specifičnih autoprotutijela i drugih seroloških pokazatelja. Metode: Presječnom studijom tijekom 2012 godine obrađeno je 115 bolesnika sa SS-om koji su liječeni na Odjela za kliničku imunologiju i reumatologiju Kliničkog bolničkog centra u Splitu. Dijagnoza bolesti je postavljena u skladu sa američko-europskim klasifikacijskim kriterijima za SS. Rezultati: Prosječna je dob oboljelih od primarnog SS-a 55 godina, a kod sekundarnog SS-a iznosi 57 godina. Najčešći je simptom suhoća sluznica prisutna u 97 % bolesnika s primarnim SS-om, te u svih bolesnika sa sekundarnim SS-om. Zglobne manifestacije prisutne su u 38 % bolesnika s primarnim SS-om, te u 83 % bolesnika sa sekundarnim SS-om. U primarnom SSu anti Ro protutijela prisutna su 93 % a anti La kod 61 % ispitanika. U sekundarnom SS-u pozitivna anti Ro protutijela prisutna su kod 95 %, a anti La protutijela kod 51 % ispitanika. Zaključak: Primarni SS u Dalmaciji je zastupljeniji od sekundarnog SS-a. U odnosu na dob nismo naišli na bitna odstupanja u usporedbi s podatcima iz literature. Potvrđena je očekivana dominacija ženskog spola u oba oblika. Klinička obilježja SS-a u Dalmaciji slična su izvješćima iz literature s pojedinim osobitostima poput rjeđe pojavnosti otoka slinovnica. Naše istraživanje pokazalo je da je prevalencija specifičnih protutijela, posebice anti La, veća u Dalmaciji u usporedbi s izvješćima iz literature. Zanimljivo je da se snižene vrijednosti komponenti komplementa C₃ i C₄ javljaju učestalije u odnosu na dosadašnja izvješća. Kao osobitost u sekundarnom SS-u zamijećena je povezanost sa spondiloartropatijom.

Aim: The aim was to investigate the prevalence of primary and secondary Sjögren's syndrome in Dalmatia, clinical features and presence of specific autoantibodies and other serological indicators of Sjögren's syndrome. Methods: We investigated 115 patients treated at Department for clinical immunology and rheumatology in Clinical hospital center Split in a cross-sectional study during 2012. The diagnosis of Sjögren's syndrome was established for all patients according to the classification critera proposed by the American-European Consensus Group. Results: Average age of patients with primary SS is 55 years and average age of patients with secondary is 57 years. The most common symptom is dryness of eyes and mouth, presented in 97% of patients with primary SS and in total number of patients with secondary SS. Articular manifestation has been presented in 38% of patients with primary SS and in 83% of patients with secondary SS. Anti Ro antibodies have been presented in 95% of patients with primary SS and in 97% of patients with secundary SS. Prevalence of anti La antibodies is 61% in primary SS and 51% in secundary SS. Conclusion: Primary SS is more common than secondary SS. There was no deviation from current reports concerning age range. The high female to male predominance of SS is confirmed in both forms. Clinical features of SS in Dalmatia are similar to the reports in the literature with particular characteristics such as less common occurrence of parotid gland enlargement. Our study revealed that the prevalence of specific antibodies, especially anti La antibodies, has shown higher than in the literature. Interestingly, the reduced values of components of the complement C₃ and C₄ occur more frequently than in previous reports. Assocciation with spondyloarthropathia has been observed as a special feature of secondary SS.