CILJ ISTRAŽIVANJA: Usporediti nalaz optičke koherentne tomografije (OCT) i funkcionalne promjene vidnog polja u pacijenata s očnom hipertenzijom i glaukomom otvorenog kuta. ISPITANICI I METODE: Istraživanjem je obuhvaćeno 68 očiju u 38 bolesnika koji su podijeljeni u dvije skupine. Grupa 1 se sastoji od 26 ispitanika (45 očiju) s glaukomom otvorenog kuta, dok se grupa 2 sastoji od 12 ispitanika (23 oka) s očnom hipertenzijom. Kod svih ispitanika je proveden cjeloviti oftalmološki pregled, OCT pregled (Cirrus HD-OCT 5000, Zeiss) za mjerenje debljine RNFL i pregled vidnog polja s Octopus 101 perimetrom (Haag-Streit Interzeag), G2 program. Podatci su prikupljeni na Klinici za očne bolesti, Kliničkog bolničkog centra Split, Medicinskog fakulteta u Splitu. U statističkoj obradi su korišteni: Pearsonov test korelacije, T test, Mann-Whitney U test. REZULTATI: U istraživanju je sudjelovalo 38 ispitanika sa 68 očiju od kojih je 12 (32%) bilo muškaraca, a 26 (68%) žena. Medijan životne dobi muškaraca iznosio je 56,6 godina (min-maks: 11-65), a žena 65 godina (min-maks: 41-80). MS u ukupnom broju očiju ima slabu pozitivnu korelaciju s prosječnom debljinom RNFL, RNFL superiorno i RNFL inferiorno. MD u ukupnom broju očiju slabo pozitivno korelira s prosječnom debljinom RNFL, a negativno s RNFL superiorno i RNFL inferiorno. Kod očiju s očnom hipertenzijom pronađena je statistički značajna razlika između debljine RNFL i indeksa MD i LV. Kod očiju s glaukomom otvorenog kuta nađena je pozitivna korelacija između debljine RNFL i indeksa MS, a negativna korelacija između debljine RNFL i indeksa MD i LV. Pronađena je statistički značajna korelacija između debljine RNFL po segmentima i globalnih indeksa vidnog polja u gornjem i donjem segmentu (P<0,05). ZAKLJUČAK: Opsežne strukturne promjene debljine RNFL mjerene OCT-om upućuju na funkcionalna oštećenja koja se otkrivaju pregledom vidnog polja. Prosječna debljina RNFL nije pouzdan parametar za ranu dijagnozu i praćenje glaukoma i očne hipertenzije, dok su promjene po segmentima glave vidnog živca (fokalne promjene) pouzdanije. Indeks vidnog polja MD je najosjetljiviji pokazatelj za praćenje napredovanja glaukoma i očne hipertenzije.

RESEARCH OBJECTIVE: The aim of this study is to compare the findings of optical coherence tomography and functional changes in the visual fields in patients with ocular hypertension and open angle glaucoma. MATERIALS AND METHODS: 68 eyes (38 patients) are enrolled in this study and they are divided into two groups. Group 1 consists of 26 patients (45 eyes) with open angle glaucoma and group 2 consists of 12 patients (23 eyes) with ocular hypertension. All of them underwent complete ophthalmic examination, OCT examination (Cirrus HD-OCT 5000, Zeiss) to measure the thickness of retinal nerve fiber layer (RNFL) and visual field with the Octopus 101 perimeter (Haag-Streit Interzeag), G2 program. This study was conducted in the Eye Clinic University Hospital Split, School of Medicine Split. In statistical analysis were used: Pearson correlation test, T test, Mann-Whitney U test. RESULTS: The study included 38 patients with 68 eyes of which 12 (32%) were men and and 26 (68%) women. The median age of men was 56,6 years (min-max) and women 65 years (min-max). When examining all eyes, MS index has weak positive correlation with average RNFL thickness, RNFL superior and RNFL inferior. A weak positive correlation is observed between MD index and average RNFL thickness, while a negative correlation is observed between MD and RNFL superior/inferior. In eyes with ocular hypertension, significant difference is found between RNFL thickness with indices MD and LV. In eyes with open angle glaucoma, positive correlation is found between RNFL thickness and MS indeks, and negative correlation is observed between RNFL thickness with MD and LV indices. The correlation between RNFL thickness by segment and global indices of visual field is found statistically significant in the superior and inferior segment (P<0,05). CONCLUSION: Extensive structural changes in RNFL thickness measured by OCT indicate functional impairment which are revealed by visual field examination. The average RNFL thickness is not reliable in early diagnosis and monitoring of glaucoma and ocular hypertension, while changes in RNFL thickness by segment (focal changes) are more reliable. The most reliable parameter in monitoring is mean defect (MD) index of the visual field.