Objectives: To determine expression of autophagy related genes p62, Beclin 1, LC3A and Atg5, as well as gene expression of necroptosis related gene Ripk3f, in bladder carcinoma compared to healthy bladder tissue of mice. Materials and methods: Experimental research was conducted at Laboratory for cancer research at University of Split School of Medicine. Wild type C57BL/6J mice 6-8 weeks old were divided into 3 groups: untreated control group, experimental group that undergone acute treatment and experimental group that undergone chronic treatment. Experimental groups were exposed to a chemical carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) administered in drinking water, in order to induce bladder carcinoma. Acute experimental group was exposed to BBN (0.05%) during 2 weeks, while the chronic experimental group was exposed to BBN (0.05%) during 12 weeks. Mice were sacrificed 2 and 20 weeks after commencement of treatment. RNA was isolated from tissue samples and then converted into cDNA by reverse transcription. cDNA was used as a template for qRT-PCR reaction. Actin gene was used as a housekeeping control. Results: Expression of p62, Beclin 1, LC3A and Atg5 was not changed in acute experimental group compared to nontreated control group. Ripk3f expression was significantly increased in both acute and chronic experimental groups compared to nontreated control group (p<0.0001; p<0.001). Conclusion: Expression of autophagy related genes p62, Beclin 1, LC3A and Atg5 is not significantly increased in bladder carcinoma in mice. Significantly increased expression of Ripk3f gene suggests that necroptosis plays an important role in pathogenesis of bladder cancer.