Objective: The main aim of this research is to explore if there is a difference in saliva secretion between patients who were using artificial saliva, and those treated with low-level laser on major salivary glandes through ten consecutive treatments, and soon after (Qs and Qss 2) or one month after therapy was over (Qs and Qss 3) in ratio of first measurment (Qs and Qss 1). Materials and methods: The reaserch contained 39 patients, diagnosed with xerostomia using sialometry test (Qs < 2.0 ml/5min). The tested group contained 14 patients who were treated with low-level laser on major salivary glandes, through ten consecutive treatments, while control group contained 25 patients, who were using artificial saliva (Caphosol) several times a day according to manufacturers guide of product instructions. Results: Results of this research indicate that increase of measured quantum of non stimulated saliva (Qs) secretion in time of ten days after laser therapy, in tested group, was slightly lower in rate of control group who was using artificial saliva through all time. Slightly lower difference was observed in increasing of salivation of stimulated saliva (Qss), but also in favour of control group. Older patients (above 70 years) were showing slightly higher Qs and Qss rate soon after laser therapy was over, regarding ten days of using artificial saliva. After one month, measurment of Qs and Qss salivation quantum rate were decreasing. Younger patients (under 70 years) were showing linear increase in quantum of salivation of stimulated and non stimulated saliva through time. Patients who were not using medication, that can cause mouth dryness, expectedly scored better results and long term better linear progression through time, in order of measured quantum salivation of nonstimulated (Qs) and stimulated (Qss) saliva. Conclusion: Results of this research indicate that increase of measured quantum salivation of non stimulated and stimulated saliva, after one month of finished laser therapy, were higher in control group patients who were using artificial saliva the whole time, according to manufacturers guide of product instructions several times a day.