Objectives: to investigate HIF-1α immunohistochemical expression in high grade and low grade endometrial carcinomas and to compared the results. Patient’s age at the time of diagnosis, tumor size, depth of myometrial invasion, presence of vascular invasion and lymph node involvement was also noted for each studied group and compared. Subject and method: 10 cases of high grade endometrial carcinoma and 10 cases of low grade endometrial carcinoma were enrolled in the study. Histological grading of endometrial carcinomas was done according to WHO 2014. Immunohistochemistry with primary antibody HIF 1α was used. For the assessment of HIF1α immunohistochemical expression HSCORE method was applied. Patient’s age at the time of diagnosis, tumor size, depth of myometrial invasion, presence of vascular invasion and lymph node involvement were noted from pathology reports. Results: Our results showed higher HIF-1α immunohistochemical expression in high grade carcinomas compared to low grade carcinomas, however this difference wasn’t statistically significant. High grade carcinomas had statistically significantly larger tumors and more frequently involved lymph nodes. Likewise high grade tumors had deeper myometrial invasion, more frequent vascular invasion and older patients at the time of diagnosis then low grade carcinomas, however these differences weren’t statistically significant. Conclusion: Our study has shown the higher immunohistochemical expression of HIF-1α in high grade endometrial carcinomas compared to low grade carcinomas, however that difference wasn’t significant.