BJECTIVES: Our goal was to examine the efficacy and safety of concurrent chemoradiotherapy as primary therapy in patients with non-small cell lung cancer stage I-III, treated at the Department of Oncology, Universitiy Hospital of Split in 2011-2018 period, and to compare our results with available up to date literature. PATIENTS AND METHODS: In a retrospective study conducted at Department of Oncology, Universitiy Hospital of Split, the data was collected on a total of 84 patients, treated with concurrent chemoradiotherapy as a primary type of therapy in a period between 2011 and 2018. Patients that received at least 1 cycle of concurrent chemotherapy have been included. We colected general data on patients and the disease (age at diagnosis, ECOG status), details about cancer grade, histology and molecular markers, data about the specific modalities and dosage of concurrent treatment (chemotherapy, radiotherapy), types of chemotherapy regimens, response to treatment and side effects of the therapy. RESULTS: The median follow-up time was 15 months. In 69% of patients (n=58) regression has been observed after treatment with concurrent chemoradiotherapy treatment. The median overall survival survival was 17 months, and median progression free survival was 9 months. Most common site of progression was in field progression (progression of tumor within the full dose radiation region). Multivariable analysis showed statistically significant association of radiotherapy dose and PFS and OS (higher dose meant longer survival), but number of administrated concurrent chemotherapy cycles was associated only with improved PFS (2 vs 1 cycle of chemotherapy). The treatment was relatively well tolerated. The most common acute toxicity was leukopenia, described in 65% of patients. Radiation esophagitis, with a 39% occurrence, was the most common acute toxicity of grade 1 and 2, while the most common grade 3 and 4 toxicity was neutropenia (38% of patients). During and 30 days after the therapy 6 patients died. CONCLUSION: This retrospective analysis on treatment outcomes of patients with locally advanced lung cancer treated with concomitant chemoradiotherapy showed comparable results in clinical efficacy and toxicity with up to date clinical trials that studied effectiveness of concurrent chemoradiotherapy.