Objectives: The aim of this study was to evaluate the knowledge and attitudes of the two study programs of the University of Split Medical School, medicine and dental medicine, toward oral cavity cancer, and to determine whether there are differences in the knowledge and attitudes between the students from the third to the sixth year studies and between each other. Materials and Methods: In this study, a cross-sectional survey was conducted using the questionnaire method. The questionnaire contained 16 questions where general data on the respondent were collected in the first part, and in the other part attitudes and knowledge toward oral cavity carcinoma. Students of two integrated studies at the Split School of Medicine, dental medicine and medicine, volunteered in the research. A total of 370 students attended, of which 130 were dental medicine and 240 in medicine. The data was entered in Microsoft Office Excel 2007 and then processed in STATISTICA 11.0. Results: The students of dental medicine know more about oral carcinoma compared to the students of medicine. The knowledge of students is also better at higher years of study. Students of both study programs do not know pre-cancerous lesions, which plays an essential role in preventing and early detection of this disease. Many dentistry students (63; 48,5 %) and most medical students (186; 77,5 %) have never independently examined the patient's oral mucous with pre-cancerous and cancerous lesions. The patient with suspicious lesion in the oral cavity would be sent to the wrong specialist of nine (7,0 %) dental students and 120 (50,0 %) medical students. Only 40 (30,8 %) of dental medicine students and 50 (20,8 %) of the medical students would have referred patients to the specialist, by the first examination of the patient with suspicious lesion in the oral cavity, if the lesion didn't heal after one week of treatment. Conclusion: In this study we have shown that there is a difference in the knowledge between medicine and dental medicine students toward oral cavity carcinoma and that knowledge changes with years of study, from the third to the sixth year. Their role as future doctors of dental medicine and medicine in preventing and early detection of this disease is very significant. The students of both studies should acquire the appropriate knowledge and skills during the studies so that they can consistently and at the right time access to the patient with a potentially malignant change in the oral cavity.