Objectives: To assess differences in exposure to life stress and to establish if there is connection between academic success and exposure to life stress, as well as if there is connection between academic success and physical and psychical health difficulties/symptoms, stressors that had an impact on the examined group over the last six months, financial difficulties and changes in lives occured on the occasion of starting universiy for 3rd and 6th year Medical students at Split School of Medicine, University of Split, academic year 2019/2020. Patients and methods: 110 students were included in the study, out of which 56 are 3rd year and 54 6th year Medical students. Data were collected online via STRAIN questionnaire, that is a questionnaire for selfassessment of stress and life difficulties. Results: There is no statistically significant difference between 3rd and 6th year Medical students in exposure to life stress. However, 6th year Medical students have more acute stressfull life events. Academic success is not connected with exposure to life stress. Academic success is not connceted with physical health difficulties/symptoms. Students with more psychical health difficulties/symptoms have lower academic success. Number and weight of stressors that had an impact on the examined group over the last six months are not connected with academic success. Financial difficulties are not connected with academic success. Students who had been exposed to more stressors, while starting university, have lower academic success. Students who had been exposed to more acute stressfull life events, while starting university, have lower academic success. Conclusion: We have proved that there is no difference in exposure to life stress between 3rd and 6th year Medical students, except in number of acute stressfull life events. We have proven that there is no connectin between academic success and exposure to life stress, as well as there is no connection between academic success and physical health difficulties/symptoms, stressors that had an impact on the examined group over the last six months and financial difficulties. We have found statistically significant connection between psychical health difficulties/symptoms and academic success, and connection between academic success total number of stressors and number of acute stressfull life events that occured on the occasion of starting universiy.