Objectives: Finding the best available evidence of efficacy and safety of gotu kola in improving the parame-ters of human skin in models of damaged skin and healthy skin. Material and methods:. The basis of the research is a search of the literature on the Medline (Pubmed) and Central database using required keywords using Boolean operators. Clinical trials were found and the studies we included in the study were selected according to the input and output criteria. A systematic review was made using PRISMA guidelines. Results: Seven controlled clinical trials were included in the study. Three of the four studies that measured skin hydration on intact skin got a statistically significant improvement in that parameter over placebo. One study examined skin hydration in a skin damage model and found no significant improvement over placebo. Two out of three studies obtained positive results on undamaged skin for skin firmness and elasticity parameters. Elasticity on healthy skin was measured by two studies and only one of them obtained results of improving the same parameter compared to placebo. One study measured elasticity on a damaged skin and noted an impro-vement over placebo. Collagen density was measured in only one study in a healthy skin model and showed an improvement in the same parameter compared to placebo. The effect of the preparations on skin relief was studied by two studies. Both studies had model of skin damage and recieved statistically significant improve-ments. One of them did not have a placebo but the active substance as a control and there was no significante difference between the test and control preparation. Transepidermal water loss (TEWL) was measured in two studies, both of them recieved a significant reduction in TEWL compared to placebo. One of them measured TEWL after the tape-stripping procedure, while the other measured TEWL in a model of skin inflammation caused by methylnicotinate. The amount of erythema was measured by two studies, one on a skin damage model and the other on healthy skin. Both studies received a statistically significant reduction in erythema. One of them did not have a placebo but an active substance as a control preparation and no statistically significant difference was obtained between the two preparations. Another study used a test preparation as a pre-treatment for damage. Skin pH was measured by only one study and obtained a statistically significant decrea-se in skin pH after skin exposure to irritant compared to placebo. Conclusion: Evidence of the effectiveness of gotu kola is limited and inconclusive due to the small number of included subjects, questionable methodological quality of studies and inconsistency of results. Therefore no reliable conlusions can be given on the effects of gotu kola on skin parameters.