Objectives: This research was aimed at gathering data on clinical features, treatment and outcome of patients diagnosed with Kawasaki syndrome in the Clinical Hospital Centre Split (KBC Split) within the period from 1995 to 2013 and compare them with the existing literature. Materials and methods: This research was conducted as an observational cross-sectional study. The data were gathered at the Clinic for Child Diseases and Clinic for Infectiology of the Clinical Hospital Centre Split (KBC Split). Age, gender, characteristic clinical symptoms, laboratory test results, transthoracic echochardiography findings, therapy and outcomes were analysed. The data were processed using descriptive statistics methods and subsequently presented in tables and graphs. Results: Twenty children with this diagnosis were treated within the given period of time. The incidence of Kawasaki syndrome in the County Split-Dalmatia was 2.8/100 000 children under the age of five and 2.2 /100 000 children under the age of ten. Gender ratio was 1:1. The average age of patients was 4.4, and 65% of all the patients were under the age of five. After conducting the adequate therapy all of the patients were successfully cured and none of them had any clinically significant cardiovascular complications. All of them met the criteria to make the diagnosis, except for one patient, who was diagnosed with atypical Kawasaki syndrome. Conclusions: Within the period from 1995 to 2013 twenty children were diagnosed with Kawasaki syndrome. The incidence of this disease in the County Split-Dalmatia was 2.8/100 000 children under the age of five and 2.2 /100 000 children under the age of ten, which is significantly below the figures registered in other countries with predominantly Caucasian population. Majority of our patients were treated within ten days from the first occurrence of the disease and none of them suffered any cardiovascular consequences typical for this illness. Vast majority of the patients (95%) met the criteria to make the diagnosis. Only one patient was diagnosed with atypical Kawasaki syndrome, which is significantly under the expected figures and leads to conclusion that atypical Kawasaki syndrome may not be recognized as often as the real one.