Objectives: Examine the results of treatment with mechanical thrombectomy in patients younger than 80 years with acute ischemic stroke caused by middle cerebral artery occlusion. Materials and methods: The study was retrospective. The respondents were patients in the Department of Neurolog in University Hospital Split in 2019. Demographic data, anamnestic data on comorbidities and previous therapy, time intervals between onset of symptoms, hospitalization, onset and end of thrombectomy, type of thrombectomy performed, NIHSS and mRS status at admission and discharge were collected. Data were taken from medical records and patient discharge letters. Results: The study involved 54 respondents, of whom 26 (50%) were men. Four (8%) subjects had a fatal outcome. The most common comorbidities were hypertension 42%, heart problems 27% and atrial fibrillation 19%. They did not affect NIHSS and mRS on admission and discharge. The median NIHSS at admission was 14 and at discharge 6.5. There was no difference in discharge with regard to stroke severity (P=0,64). Functional independence at discharge was achived in 16 (31%) patients. MRS on admission did not affect MRS on discharge (P=0,23). The median total time from onset of symptoms to thrombectomy is 211 minutes. Patients who were treated more than 6 hours after the onset of symptoms had poorer NIHSS scores on discharge (P=0,03) although they did not show differences in achieved reperfusion (TICI) (P=0,075). In all subjects, the aspiration technique was used during thrombectomy, while in 29% a stent retriever was used. Satisfactory TICI score (2b-3) among all subjects was achieved in 41 (78%). There was no difference in reperfusion (P=0,24) and discharge mRS score (P=0,348) between patients who received IVT with thrombectomy and patients who were treated only with thrombectomy, but patient who received IVT showed a larger NIHSS difference (10 in comparison with 6 in patients without IVT). Bleeding on control MRCT was shown in 8 (15%) subjects. The median duration of hospitalization was 8 days in an interval of 1 to 28 days. Conclusions: Thrombectomy is a successful method for treating acute ischemic stroke. The time longer than 6 hours from the onset of symptoms until thrombectomy had negative impact on treatment outcomes. IVT administration prior to thrombectomy resulted in better early recovery outcomes. Comorbidities have no effect on treatment success.