Objectives: Collect data on the number of people hospitalized for COVID-19 and lymphoma in the Clinical Hospital Center (KBC) Split in the period from March 2020 to June 2022, classify patients by gender, age group and hematological diagnosis. To determine the number of hospitalizations and the influence of sex, age, hematological diagnosis and disease activity on the number of hospitalizations, the use of oxygen therapy and the outcome of the disease. To assess the effect of therapy, especially rituximab, on the clinical picture, the number of hospitalizations and the outcome of COVID-19. Show the influence of laboratory parameter values on the outcome of the COVID-19 disease. Subjects and methods: The data required for the work were collected from the medical history of the patients, which are stored in the archives of the Infectious Diseases Clinic, KBC Split. The collected data were entered into Microsoft Excel for data processing and presented in the word processing program Microsoft Word. Results: The study included 51 patients with a total of 74 hospitalizations due to SARS-CoV-2 infection. It was shown that 58.82% of patients were men, and the most common average age of those hospitalized was 67.77 years. The most common diagnosis among patients with lymphoma and COVID was large cell diffuse B lymphoma (45.10%). The average number of hospitalizations was 1.877, and the highest number of hospitalizations was found in the age group of 51 to 60 years. Recovery followed in 81.69%, and as many as 11.27% of cases resulted in death. Patients diagnosed with other indolent lymphomas had the worst prognosis, their average number of hospitalizations was 2.286. Also, in patients under anti-CD20 maintenance therapy, a higher number of hospitalizations during the treatment of COVID-19 has been demonstrated. Oxygen therapy was most often used in patients aged 71 to 80 years, while it was not necessary in those younger than 60 years. Patients with a high and very high 4C-mortality score were more often treated with oxygen. A significantly higher number of deaths was demonstrated in the group of patients previously treated with rituximab. The use of therapy that includes corticosteroids, remdesivir and convalescent plasma did not affect the outcome of the disease compared to the group that did not receive the specified therapy, more precisely in both groups the highest number of recoveries from SARS-CoV-2 infection was recorded. Conclusion: Patients with a confirmed diagnosis of SARS-CoV-2 infection and a diagnosis of indolent lymphomas and lymphomas under maintenance therapy have a higher risk of relapse of COVID-19 and therefore have a higher number of hospitalizations. Prior treatment with a monoclonal anti-CD20 antibody resulted in a higher mortality rate in patients with COVID-19. Oxygen therapy was most often used in the age group of 71 to 80 years, especially in patients with a high and very high 4C-mortality score.