Introduction: Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. Methods: This doctoral thesis consists of 4 studies that i) systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials (RCTs) on interventions for NeuP, ii) assessed outcome domains and measures used for the assessment of treatment efficacy and safety, iii) the methodological quality of included SRs, and iv) awareness and acceptability of Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT)-recommended core outcome set (COS) and core outcome measures (COMs) for chronic pain among authors of SRs. Results: The most common interventions in 97 included SRs were pharmacological (59%) and surgical (15%). The majority of analyzed SRs were of medium quality. More than 50% of conclusions from abstracts on efficacy and around 80% on safety were inconclusive. The included SRs reported a median 4 out of 6 IMMPACT core domains. Pain intensity was mostly assessed with VAS (n=59) and NRS (n=29) scales. Authors of NeuP SRs insufficiently use relevant recommended COS because they are not aware of or they find it irrelevant. Conclusions: Evidence about interventions for NeuP is frequently inconclusive or completely lacking. The methodological quality of analyzed SRs in the field of NeuP was not optimal. Further work on the IMMPACT COS is needed, in terms of evaluating its adequacy and uptake among authors.