The aim of this study was to determine the causal factors for the development of the infection of the female genital tract and their correlation with different predictor variables taking into account the lifestyle and general health status. The role of low molecular weight metabolites produced by Candida species in the infections development and usability of the micronucleus test as a cytogenetic technique in the prediction of the infection was also examined. 203 women in the age range from 18 to 65 years were included in the study. After the completion of questionnaire all the patients were subjected to Pap test, cervical swabs for the presence of aerobic bacteria, yeasts, Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma, and hrHPV DNA. Separate samples of vaginal secretion were taken for GC-MS analysis of metabolites and micronucleus assay. A significant correlation between the predictor variables (lifestyle and health status) and dependent variables (results of Pap tests and cervical smears) was confirmed. GC-MS analysis confirmed the presence of the metabolite 2-phenylethanol in vivo in 14 of 74 samples tested. In 9 out of 14 samples the presence of metabolite could be related to Candida species. The symptoms, hrHPV and Ureaplasma urealyticum were the predictor variables with the highest influence on the formation of the metabolite in vivo. In vitro results confirmed that the Candida species produce 2-phenylethanol in the concentrations ranging from 0.6-4.64 mg/mL. The formation of 2-phenylethanol, both in vivo and in vitro, was confirmed and connected with Candida species. Besides, according to statistical tests it seems that presence of symptoms, hrHPV DNA and Ureaplasma urealyticum had also significant role on the formation of 2-phenylethanol in vivo. Number of micronuclei per 1000 vaginal epithelial cells ranged from 0 to 22 with the mean value of 7.17. Higher values were associated with the exposure to X-rays during medical examination and regular alcohol consumption. The patients with cervical lesions, presence of hrHPV DNA and/or Chlamydia trachomatis also exhibited increased values of micronucleated cells.