Objectives: The aim of this research was to determine the impact of e-informed consent and additional information on HPV vaccination coverage among children after the application was introduced in the school clinics of the Split-Dalmatia County. Further objectives were to determine if simultaneous vaccination (Gardasil 9® and Dultavax®) affects the HPV vaccination coverage of children in the final grade of elementary school and whether encouraging students from the fifth to eighth grade for HPV vaccination additionally increased the overall vaccination coverage of children up to the age of fifteen. Participants and methods: Data were collected on the number of children vaccinated against HPV over the past five school years (2019/20 - 2023/24) in Split-Dalmatia County. This included reviewing the Teaching Institute of Public Health of Split and Dalmatian County vaccination register and electronic records from the Prevention complete program to define the total number of vaccinated children. The Terminko® application provided data on children vaccinated after e-informed consent and those whose parents sought additional information before vaccination. Results: Of the total number of vaccinated students in the 2022/23 school year, 41.40% used e-informed consent, and in the 2023/24 school year that percentage rose up to 70.79%. In the 2022/23 school year, 60.49% of parents decided to vaccinate their child after receiving additional information, making up 7.79% of the total number of vaccinated that year. In the 2023/24 school year, 66.94% of students were vaccinated after additional information, making up 27.79% of the total number of vaccinated that year. In the 2022/23 school year, 9.96% of the total number of vaccinated eighth-grade students were vaccinated simultaneously, and in the 2023/24 school year, 69.99% were vaccinated simultaneously. Fifth, sixth, and seventh-grade students made up 53.23% of the total number of vaccinated in the 2022/23 school year, and 45.71% in the 2023/24 school year. Conclusion: The introduction of e-informed consent starting from the 2022/23 school year in combination with the possibility of additional parent information had a positive impact on HPV vaccination coverage among children in the Split-Dalmatia County. Simultaneous vaccination (Gardasil 9® and Dultavax®) from the 2022/23 school year did manage to increase the HPV vaccination coverage of students in the final grade of elementary school. Encouraging fifth to eighth-grade students to get the HPV vaccine from the 2022/23 school year additionally increased the vaccination coverage of children up to the age of fifteen.