Objective: To analyze the connection between the intensity of nestin expression in the podocytes and the clinical syndrome and renal function parameters at the time of biopsy in patients with immunoglobulin A nephropathy. Design: Retrospective study. Settings: Department of Pathology, Forensic Medicine and Cytology, Split University Hospital. Participants: Paraffin blocks of percutaneous renal biopsies from 24 patients with IgA nephropathy and Henoch-Schönlein purpura were collected from the archives of the Department of Pathology, Forensic Medicine and Cytology. Histological samples were studied by means of an indirect immunohistochemical method; they were cut and stained with mouse anti-human antibody to nestin. Data on blood pressure, clinical syndrome and renal function laboratory values at the time of biopsies were taken from the archives of the Department of Pediatrics and the Department of Internal Medicine, Split University Hospital. Main Outcome Measures: The degree of nestin expression is associated with changes in biochemical markers of renal function. Results: The intensity of nestin expression in IgA nephropathy and Henoch-Schönlein purpura was significantly negatively correlated with creatinine clearance (P=0.02). Nestin expression was not associated with the value of 24-hour proteinuria or serum creatinine (P=0.689 and 0.543). There was no connection between nestin expression and presented renal syndrome (P=0.739). Nestin expression was not associated with systolic and diastolic pressure at the time of biopsy (P=0.94 and P=0.640). Conclusions: The expression of nestin in the podocytes in IgA nephropathy is associated with glomerular damage. The decline in the glomerular filtration rate, manifest as a decline in creatinine clearance, is accompanied by an increase in nestin expression in the podocytes. This observation needs further research to substantiate the role of nestin in nephropathies.