Objectives: The analysis of the results of the impact of implementation of temozolomide in everyday clinical practice in the treatment (OS, PFS) of patients with glioblastoma at the Department of Oncology and Radiotherapy, Clinical Hospital Split in the periods from 2002 to 2004 and from 2009 to 2011. A review of the epidemiology of glioblastoma at the Department of Oncology and Radiotherapy, Clinical Hospital Split. Material and methods: In a retrospective study conducted at the Department of Oncology and radiotherapy Clinical Hospital Split the data was collected on a total of 113 patients in both periods together. We colected general data on patients and the disease (age at diagnosis, type of surgery, hospital where the surgery was conducted, ECOG status), data about the specific modalities of cancer treatment (chemotherapy, radiotherapy), types of chemotherapy regimens (CCNU / vincristine, temozolomide), response on cancer-specific oncology treatment and side effects of the therapy. Results: There was a slight decline in the incidence of primary brain tumors in Croatia in the last 15 years. In the first period from 2002 to 2004 The Clinical Hospital Split recorded 4.75% of new cases of primary brain tumors and 7.8% in the second period from 2009 to 2011. In both periods the majority of these tumors were glioblastomas (56.33% and 67.27%). The number of patients who came for treatment at the Department of Oncology and Radiotherapy, Clical Hospital Split after surgery has increased over the years (40 patients in the first period versus 73 in the second period). Radiotherapy then chemotherapy was replaced by concomitant chemoradiotherapy with temozolomide as the first line therapy in newly diagnosed glioblastomas. The median of survival was increased from 9 months during the first period to 10 months in the second period. Conclusios: The Department of Oncology and Radiotherapy of the Clinical Hospital Split, Following the latest guidelines, recorded good results in the treatment of glioblastoma. The median overall survival of 9 months in the first period and 10 months in second period are near the results of the world's leading institutions in those periods. The introduction of temozolomide in the year 2007. at the Department of Oncology and Radiotherapy Clinical Hospital Split has had a modest impact on the treatment and survival of patients with glioblastoma. There was an increase in patients who came for specific oncological treatment for glioblastoma to the Department of Oncolgy Clinical Hospital Split over the years.