OBJECTIVES: The aim of this research was to determine the main demographic and pre-dispositional factors in patients diagnosed with liver abscesses and to investigate the main symptoms and laboratory reports in order to conclude which bacteria is the most common cause of liver abscess, and therefore suggest the best empirical antimicrobial therapy. MATERIALS AND METHODS: The research was done on the corpus of 25 patients with determined liver abscess who were treated in Infectology Department of Clinical Hospital Split in the period of 10 years (2005-2015). Retrospective observational study was performed with the insight into the history of illness and discharge letters of the patients. RESULTS: Diabetes type 2 was confirmed in almost 50 % of the patients. The most common initiator was biliary system (acute cholangitis and cholecistitis) in 40% of the patients. Other factors of risk or the initiators of infections were colon cancer, pyelonephritis, pancreatitis and asplenia. The most common symptom was fever, in 100% of our patients. More than half of the patients had high fever (>39 º C). 68% of the patients felt spontaneous abdominal pain, differently localized. The second most common symptom that 48 % of the patients complained was dry cough. Blood test showed higher CRP in 100% of the patients. 76% of the patients had leukocytosis and 88% neutrophilia. GGT was higher in 72% of the patients and alkaline fosfatase in 44%. High bilirubin was found in 36% of the patients. The most common isolated cause was K. Pneumoniae, that was isolated from 3 hemocultures. 11 patients (44%) diagnosed with abscesses smaller than 5 cm were treated with antimicrobial therapy. CONCLUSION: Most of our patients were diagnosed with diabetes mellitus and biliary and pancreas system illnesses. The illness mostly manifested as a fever of unknown cause, and no other symptom was common enough to point to the infection localization. Abdomen CT scan is more reliable than ultrasound in liver abscesses diagnosis. Enterobacteriaceae with or without B. fragilis were the most common isolated bacteria from hemoculture . Its antibiotic sensitivity justifies empirical use of wide specter beta-lactam such as co-amoxiclav or ceftriaxone in combination with metronidazole. Drainage was not performed with the patients diagnosed with abscesses smaller than 5 cm if they responded to the antibiotic therapy with temperature decrease and inflammatory blood parameters.