Objectives: The aim of this study was to investigate the genetic background underlying increased risk of developing tuberculosis. Methods: A subset of the 10,001 Dalmatians study data were used for purpose of this study. We performed a genome-wide association analysis of the subjects who had a medical record of hospital admission due to tuberculosis. All other subjects who were not admitted to hospital for tuberculosis treatment were considered as controls. Results: A single significant result (at the formal significance level cut-off value of 3*E-08), belonging to the CECR6 gene was recorded. Additionally, DSCAM, FOXK2 and KLF8 yielded nearly significant result, supporting the previous idea of complex genetic background risk definition. Discussion: This is the first report of the CECR6 gene in tuberculosis pathogenesis, which is in line with the biological functions previously described for this gene. The additional three genes also seem to have roles that can easily be associated with tuberculosis. The genetic architecture underlying tuberculosis seems to be very complex, and requires larger-scale analyses in order to be able to develop a diagnostic tools and provide individualized prevention measures in the future, by focusing on individuals that have the highest underlying risk for contracting and developing clinically relevant disease.