Objectives: The aims of this study were to investigate the liver enzymes, bilirubin serum levels, lipid profile, and cardiovascular risk in patients with oral lichen planus (OLP) compared to control subjects. Materials and Methods: Patient medical data (OLP and control group) included age, gender, smoking status, alcohol consumption, the existence of liver diseases, and diabetes mellitus. Height and weight were measured using a stadiometer and a balance beam scale to calculated body mass index. Also blood pressure measurements were performed for each patient. Fasting blood samples were obtained for each study participant (n = 126) to determine total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides serum levels as part of routine lipid profile, as well as levels aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase and total bilirubin. Cardiovascular risk was calculated for each patient according to the European society of cardiology low cardiovascular risk chart based on gender, age, smoking status, systolic blood pressure, total cholesterol, and HDL-c. The subjects for the control group (n = 63) were recruited from a pool of healthy subjects whose clinical examinations showed no signs of any oral lesions. Results: We found significantly higher total bilirubin levels (P=0.04) and a higher incidence of liver disease (P=0.04) in OLP patients compared to the control subjects. All tested lipid profile parameters were elevated in more OLP patients than control subjects but without statistically significant differences. The mean values of calculated cardiovascular risk were similar in the experimental and control groups. Conclusions: The exact mechanism that exists between the association of chronic liver disease and OLP still remains unclear, and further studies involving a larger number of patients are required to validate this association. Further research on lipid levels and cardiovascular risk in OLP are also required to establish the findings of this study.