Objectives: The main objectives of this research were to investigate if there was a difference between the frequency of pathological changes in oral mucosa and the presence of subjective symptoms in oral cavity between the study group (subjects diagnosed with GERD) and the control group (withouth GERD). Materials and methods: The research was conducted by comparing the study group consisting of 18 subjects diagnosed with GERD and the control group of 18 healthy individuals. Anamnestic data was collected for all of the individuals, including age, gender and everyday habits, such as consuming cigarettes, alcohol and coffee. After conducting the esophagogastroduodenoscopy at University Hospital Split, the Department of Gastroenterology and Hepatology, subjects who had been diagnosed with GERD were included in the study group. All the included subjects underwent detail clinical examination of the oral cavity. Pathological changes and their localization have been recorded and all of the subjects provided information about subjective symptoms of stinging and/or pain in the oral cavity. Results: The mean value of the pathological lesions on the oral mucosa was statistically significantly higher (P = 0.003) in the group of patients diagnosed with GERD, as well as the appearance of subjective symptoms (P = 0.008). The most common pathological change on the oral cavity mucosa in the study group was erythema (33.33%), while the most common localization were palatal arches (66.67%). Correlation between daily habits (consumption of alcohol, cigarettes and coffee) and pathological lesions on the oral cavity mucosa in examinees with GERD was not significant. Conclusions: Previous findings have shown that there is a correlation between gastroesophageal reflux and the appearance of pathological changes on the oral cavity mucosa which was also shown in this study. Subjective symptoms in the oral cavity were significantly more pronounced in subjects diagnosed with GERD, while there was no association between those nuisances and daily habits of consuming alcohol, cigarettes and coffee.