Objective: Determine how long it takes for complete phonation adjustment to new dentures. Examine whether factors such as gender, age, period of being edentulous and experience with mobile dentures affect adjustment time. Materials and methods: The study involved 30 patients, 22 women and 8 men, who came for new complete dentures. Patients filled in data on gender, age, type of previous and present therapy, period of being edentulous and were required to rate phonation satisfaction with new dentures on days 1, 3, 8, 15, and 30 through VAS questionnaire (1-10, 1 - completely dissatisfied, 10 - completely satisfied). Results: The results of this study showed that patients’ satisfaction with phonation increased statistically significant from day 1 to day 30, P = 0.013. There was a statistically significant difference in the time of adjustment between the genders, P = 0.04. Women were initially more satisfied with phonation, but after 30 days satisfaction was the same. Patients' age did not have influence on satisfaction with phonation and a statistically significant difference was not found between the groups of different age. For the first 15 days, the most satisfied were the patients of the youngest group, while the adjustment of the oldest group took the most time. On the thirtieth day, the oldest group was more satisfied than the youngest group of patients. Period of being edentulous and previous therapy did not significantly affect adjustment time and no statistically significant difference was found, but the results suggest that longer adjustment time is needed for patients who have a shorter period of being edentulous and have no experience with mobile dentures. Conclusion: Based on the results, it was found that a minimum of one month is required for full adjustment. There was statistically significant difference in the time of adjustment to phonation with new dentures depending on gender. Age, period of being edentulous and previous experience with mobile dentures also affected adjustment time in the beginning, but we were unable to prove it statistically.