Objectives: The aim of this study is to evaluate the epidemiological and clinical features of contact dermatitis. We used the experience of the dermatovenerological clinic of the Clinical Hospital Center Split, from 2013 to July 2019. It is of great significance and importance to collect and analyze Patch Test data over a period of time, in order to recognize epidemics and trends of contact dermatitis. If a specific trend or epidemic is recognized by the analysis, it is important to ask and search for possible causes. This in turn can lead to future disease prevention and health benefits for the whole population. There can be many reasons for a specific trend or epidemic in the population. It could be due to the water supply system, air pollution, specific cosmetics using unrecognized irritants and furthermore. Materials and methods: An epidemiological study was conducted with the data from patch test results of the allergological ambulance from 2013 till July 2019 at the department of Dermatology and Allergology, Clinical Hospital Centre Split. The data collection included 3228 patients in total, whereof 2279 patients were of female gender and 949 were of male gender. As explained above, we included twenty-three allergens in our study, based on the Patch Test model in the Dermatovenerological Department of the Clinical Hospital Centre Split. The results were interpreted from a weak positive reaction (+), strong positive reaction (++) up to an extreme positive reaction (+++/++++). We also included a time-lapse factor, including the reaction after 48 hours and the reaction after 72 hours. Results: There is a high incidence of Cobalt Chloride 1% associated contact dermatitis in our study population. Overall, the allergens revealed a higher incidence of reaction after 48 hours and declining incidence after 72 hours. Nickel Sulfate 5% exhibited a more severe reaction than other allergens. The frequency of combination between the allergens was especially high for Cobalt Chloride 1%, which occurred together with almost all allergens. Conclusion: We can observe a specific trend of contact dermatitis in our study population. There are differences in the results when comparing the female and male population. Furthermore, we studied that there is a difference in the reaction after 48 hours and 72 hours in our study population. There is a difference in the severity of reaction for each allergen. Many combinations are observed between the different allergens.