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THE EXPRESSION OF PROINFLAMMATORY CYTOKINES IN THE RENAL CELL CARCINOMA COMPARED TO THE HEALTHY KIDNEY TISSUE
CROSS-SECTIONAL STUDY
Martina Koprčina (2012)
University of Split
School of Medicine
Cite this document

Koprčina, M. (2012). IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:537464

Koprčina, Martina. "IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA." Master's thesis, University of Split, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:171:537464

Koprčina, Martina. "IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA." Master's thesis, University of Split, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:171:537464

Koprčina, M. (2012). 'IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA', Master's thesis, University of Split, School of Medicine, accessed 21 September 2019, https://urn.nsk.hr/urn:nbn:hr:171:537464

Koprčina M. IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA [Master's thesis]. Split: University of Split, School of Medicine; 2012 [cited 2019 September 21] Available at: https://urn.nsk.hr/urn:nbn:hr:171:537464

M. Koprčina, "IZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA", Master's thesis, University of Split, School of Medicine, Split, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:171:537464

Metadata
TitleIZRAŽAJ PROUPALNIH CITOKINA U TKIVU ADENOKARCINOMA BUBREGA U USPOREDBI SA ZDRAVIM BUBREŽNIM TKIVOM : PRESJEČNA STUDIJA
Title (english)THE EXPRESSION OF PROINFLAMMATORY CYTOKINES IN THE RENAL CELL CARCINOMA COMPARED TO THE HEALTHY KIDNEY TISSUE : CROSS-SECTIONAL STUDY
AuthorMartina Koprčina
MentorJanoš Terzić (mentor)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2012, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
CILJ ISTRAŽIVANJA: Cilj istraživanja je otkriti postoji li značajna razlika u izražaju proupalnih citokina TNF-α, IL-6 i IL-1β u tumorskom tkivu bubrega u odnosu na zdravo bubrežno tkivo. USTROJ ISTRAŽIVANJA: Presječna studija. MJESTO ISTRAŽIVANJA: Istraživanje je provedeno u laboratoriju Katedre za imunologiju i genetiku, Medicinskog fakulteta u Splitu i na Odjelu za urologiju, Kliničkog bolničkog centra Split. SUDIONICI: Istraživanjem je obuhvaćeno 24 uzorka bubrežnog tkiva. Od toga je bilo 12 uzoraka zdravog bubrežnog tkiva i 12 uzoraka adenokarcinoma bubrega gradusa 2. Svi uzorci uzeti su operacijskim zahvatom na Odjelu za urologiju, KBC-a Split. GLAVNA MJERA ISHODA: Glavna mjera ishoda je povećani izražaj proupalnih citokina u tkivu adenokarcinoma bubrega, dokazana reakcijom RT-PCR. REZULTATI: Istraživanjem je obuhvaćeno 24 uzorka tkiva. Od toga je bilo 12 tumorskog tkiva, a 12 zdravog tkiva bubrega. Obradom podataka, dobili smo statistički značajan porast IL-6 u tumorskom tkivu bubrega (P<0,05). Vrijednosti porasta TNF-α i IL-1β nisu bile statistički značajne. ZAKLJUČCI: Značajan porast IL-6 u tumorskom tkivu bubrega upućuje na povezanost upale i nastanka karcinoma bubrega svijetlih stanica.
Abstract (english)
OBJECTIVE: The aim of the study is to determine expression level of proinflammatory cytokines TNF-α, IL-6 and IL-1β in renal cell carcinoma (compared to the healthy kidney tissue). DESIGN: The study was designed as a cross-sectional study. SETTINGS: The study was carried out at the Department of Imunology and Genetics, at the Medical University Split and the Department of Urology, University Hospital Centre Split. PARTICIPANTS: The study consisted 12 was renal cell carcinoma tissue, and the 12 healthy kidney tissue samples. All of the samples were collected during an operational procedure at the Department of Urology, University Hospital Centre Split. MAIN OUTCOME MEASURES: Main outcome measure is a elevated expression of proinflammatory cytokines in the renal cell carcinoma tissue, which has been detected by RT-PCR approach. RESULTS: We found a statistically significant increase of IL-6 expression in the tumor tissue, compared to the healthy kidney tissue (P<0,05). The increase in expression of TNF-α and IL-1β was not statistically significant. CONCLUSIONS: We found a significant increase in IL-6 in tumor tissue, which indicates connection between inflammation and renal carcinogenesis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:537464
Study programmeTitle: Medicina
Study programme type: sveučilišni
Study level: integrirani preddiplomski i diplomski
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsRestricted access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
Created on2016-05-13 09:37:21