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master's thesis
54   17
HUMORAL IMMUNITY IN PATIENTS WITH ORAL LICHEN RUBER
Matea Ćurčija (2017)
University of Split
School of Medicine
Oral medicine and parodonthology
Metadata
TitleHUMORALNA IMUNOST U OSOBA OBOLJELIH OD ORALNOG LIHEN RUBERA
AuthorMatea Ćurčija
Mentor(s)Dolores Biočina-Lukenda (thesis advisor)
Abstract
Oralni lihen ruber je kronična mukokutana autoimuna bolest nerazjašnjene etiologije. Smatra se da alteracija keratinocita stimulira početak imunoreakcije ili imunoreakcija dovodi do preobrazbe keratinocita. Cilj ovog istraživanja je bio utvrditi stanje humoralne imunosti kod oboljelih od OLR-a. U ispitivanju je sudjelovalo 30 osoba oboljelih od OLR-a i 30 zdravih osoba kao kontrolna skupina. Humoralna imunost određena je utvrđivanjem vrijednosti IgG, IgM i IgA u serumu. Rezultati su pokazali značajno povišenje razine IgA i IgM u pacijenata s OLR-om, te neznačajno povišene razine IgG. To govori o sistemnoj imunoreakciji kod oboljelih i moglo bi pomoći u razumijevanju patogeneze ove bolesti.
KeywordsLichen Planus Oral Immunity Humoral
Parallel title (English)HUMORAL IMMUNITY IN PATIENTS WITH ORAL LICHEN RUBER
GranterUniversity of Split
School of Medicine
Lower level organizational unitsOral medicine and parodonthology
PlaceSplit
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeDental Medicine
Academic title abbreviationdr. med. dent.
Genremaster's thesis
Language Croatian
Defense date2017
Parallel abstract (English)
Oral lichen ruber (OLR) is a chronic mucocutaneous autoimmune disease with unknown etiology. Either alteration of keratinocytes stimulates the beginning of the immunological reaction or keratinicyte changes are result of a immunological reaction. The aim of this study was to investigate humoral immunity of patients with OLR. The study sample consisted of 30 patients with OLR and 30 healthy participants who were serving as control group. Humoral immunity was determined with concentration of immunoglobulins IgG, IgA and IgM in serum. Results showed significantly elevated values of IgA and IgM in serum of patients with OLR and unsignificantly elevated value of IgG. Results showed that sistemic immunoreactin was present in patients with OLR and it could help understanding pathogenesis of this disease.
Parallel keywords (Croatian)Oralni lihen planus Humoralna imunost
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:171:275705