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Evocirani potencijal P300 u bolesnika s blagim spoznajnim oštećenjem
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Stipe Medvidović CILJ ISTRAŽIVANJA:
Prikazati razlike amplitude i latencije vala P300 između ispitanika s blagim spoznajnim
oštećenjem i ispitanika iz kontrolne skupine.
USTROJ ISTRAŽIVANJA:
Provedena je presječna studija u trajanju od 1. travnja 2012. god. do 10. srpnja 2012. god.
Glavni kriterij uključivanja bila je dijagnoza blagog spoznajnog oštećenja.
MJESTO ISTRAŽIVANJA:
Istraživanje je provedeno na Klinici za neurologiju KBC-a Split, referentni centar za evocirane
potencijale...
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Explorative study about the effect of classical music on procedure related anxiety in patients with peripheral artery disease
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Johannes Pampel Objectives: The aim of this study was to evaluate a newly assembled classical music playlist
with a qualitative survey as well as its effect on procedure related anxiety measured with mNRS
and physiologic parameters in patients with peripheral artery disease (PAD). Therefore, patients
receiving percutaneous transluminal angioplasty (PTA) where randomly assigned to a music
and control group. In addition, anamnestic and demographic data was analyzed.
Subjects and methods: 25 patients were...
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Expression of hypoxia-inducible factor-1 alpha (HIF-1α) in high grade and low grade endometrial carcinomas
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Leon Romeo Schmid Objectives: to investigate HIF-1α immunohistochemical expression in high grade and low grade endometrial carcinomas and to compared the results. Patient’s age at the time of diagnosis, tumor size, depth of myometrial invasion, presence of vascular invasion and lymph node involvement was also noted for each studied group and compared.
Subject and method: 10 cases of high grade endometrial carcinoma and 10 cases of low grade endometrial carcinoma were enrolled in the study....
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Expression of inversin and DVL-1 in the liver of yotari (Dab1-/-) and wild-type mice
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Vanessa Elena Preid Galešić Objectives: Invs and DVL-1 expression patterns in the liver of yot (Dab1-/-) mice are
the focus of this study, which attempts to clarify their possible roles in the pathophysiology of
hepatic abnormalities linked to the Dab1 loss. This study aims to advance knowledge of the
molecular processes that underlie the emergence of hepatic dysfunction in the context of Dab1
disruption, elucidating possible ramifications for hepatic physiology and associated treatment
approaches.
Materials and...
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Expression of vitamin D receptors in the superior cervical ganglia of rats
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Genia Marlen Gordana Kretzschmar Objectives: We investigated the distribution of vitamin D receptors (VDR), 1α-hydroxylase (1-α- OHase/ CYP27B1), 24-hydroxylase (CYP24) in neuronal subpopulations and satellite glia in the superior cervical ganglia (SCGs) of rats.
Materials and methods: Four male Sprague-Dawley rats were raised under controlled conditions. The rats were sacrificed at twelwe weeks of age, and their superior cervical ganglia embedded in paraffin and prepared for immunohistochemistry. The intensity of...
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Expression pattern of Snail in the kidneys of streptozotocin-induced diabetic rats
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Samy Mehdi Ksouri Objectives: The most prevalent cause of chronic kidney disease is diabetic nephropathy (DN), which can lead to end-stage renal disease (ESRD) and premature death in developed countries but knowledge about these changes is still unsatisfactorily. Specific factors can be used to study developmental pathways and changes in rat diabetic kidneys. Snail is a superfamily of genes that has been found to control gastrulation and neural crest EMT through E-cadherin down-regulation. Snail is located in...
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Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis
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Julian Kaufman Objectives: The purpose of this study is to investigate the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hip of human patients with osteoarthritis according to their disease severity.
Materials and methods: Total hip arthroplasty with tissue extraction from the weightbearing area of the pathologic femoral head was performed on all patients. Patients were divided into two groups according to their disease severity defined by their Kellgran Lawrence,...
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Expression pattern of apoptosis-inducing factor in the kidneys of streptozotocin-induced diabetic rats
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Tim Julian Hauke Objectives: The aim of this study is to investigate the significance of AIF expression in the development of DKD by observing the expression of AIF in 2 weeks and 2 months diabetic kidney samples and then comparing them to healthy rat kidneys of the same age.
Materials and methods: Diabetes mellitus (DM) was induced by i/p injecting 55 mg/kg streptozotocin (STZ) to male Sprague-Dawley rats, and was validated by measuring blood glucose level. Control group received citrate buffer. Animals...
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Extended molecular testing of consecutive tumor specimen and subsequent treatment
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Finja Marie Schwenkenbecher Objectives: The purpose of this study is to confirm, whether detailed genetic testing of
patients with advanced tumor stage provides the basis for new molecular targeted therapies
and to determine, if detailed genetic testing extends treatment options and improves the
outcome. In addition, the frequency of molecular alterations and their level of evidence were
determined in an unselected group of patients. Furthermore, we investigated the frequency of
targetable genomic aberrations and...
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Factors associated with left atrial myopathy in patients with sinus rhythm
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Eva-Maria Gertrud Jakob Objectives: This study’s main aim was to identify factors that are associated with the
development of left atrial myopathy in patients without atrial fibrillation. The hypothesis states
that left atrial myopathy can be detected in patients without atrial fibrillation and it is correlated
to comorbidities.
Materials and methods: Sixty-five consecutive patients (40 male, 57.65 ±13.6 years old) with
normal sinus rhythm (SR) and without a history of atrial fibrillation (AF) underwent...
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Farmakoekonomske analize ljekarničkih usluga
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Ana Božinović - Karauz Cilj istraživanja: Cilj ovog diplomskog rada je osvrt na izdvojene recenzirane studije koje donose rezultate o učinkovitosti, uspješnosti i isplativosti provedenih farmakoekonomskih analiza ljekarničkih usluga. Kontekst ovog istraživanja su ljekarničke usluge u Hrvatskoj koje još uvijek nisu vrednovane, ali postoji potreba da se troškovi pružanja ljekarničkih usluga kvantificiraju.
Ispitanici i metode: Za izradu ovog diplomskog rada pretraživanje literature je provedeno od 1....
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Farmakoterapija bolesnika sa šećernom bolesti hospitaliziranih zbog SARS-CoV-2 infekcije
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Ivana Šumera Cilj istraživanja: Cilj ovog istraživanja bio je usporediti farmakoterapiju bolesnika sa šećernom bolesti pri prijemu u bolnicu zbog bolesti COVID-19, u odnosu na farmakoterapiju bolesnika sa šećernom bolesti pri otpustu iz bolnice.
Materijali i metode: U svrhu istraživanja prikupljeni su podatci 40 bolesnika sa šećernom bolesti hospitaliziranih u KBC-u Split zbog infekcije SARS-CoV-2 u periodu od listopada do prosinca 2021. godine. Kriterij uključenja ispitanika u istraživanje...
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