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Apoptotsko djelovanje tienopiridinskog derivata na stanice humanog karcinoma grlića maternice
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Dora Jerčić Cilj istraživanja: Cilj istraživanja bio je dokazati apoptotsko djelovanje tieno[2,3-b]piridinskog derivata (E)-3-amino-5-(3-(3-bromfenil)akriloil)-N-(3-kloro-2-metilfenil)-6-metiltieno[2,3-b]piridin-2-karboksamida (inhibitor 8) na stanice humanog karcinoma grlića maternice staničnih linija HeLa i SiHa.
Materijali i metode: MTT testom provedeno je ispitivanje citotoksičnosti na staničnim linijama HeLa i SiHa te je određena potrebna koncentracija inhibitora 8 kojom je ispitivano...
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Apoptotsko djelovanje tienopiridinskog derivata na stanice humanog karcinoma jajnika
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Lara Karanušić Cilj: Cilj ovog istraživanja jest dokazati djelovanje sintetski dobivenog inhibitora iz skupine tieno[2,3-b]piridina na apoptozu stanica staničnih linija SK-OV-3 i OVCAR-3 humanog karcinoma jajnika. Pretpostavljeno je da će se nakon tretiranja tumorskih staničnih linija inhibitorom postotak stanica u ranoj, kasnoj te ranoj i kasnoj apoptozi ukupno, povećati.
Materijali i metode: Pomoću MTT metode određena je optimalna koncentracija inhibitora kojom su tretirane stanice staničnih...
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Arterial stiffness in patients with severe obstructive sleep apnea
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Tomislav Daniel Medved Objectives: Obstructive sleep apnea (OSA) could have detrimental effects on overall patients’ health. Moreover, OSA without other comorbidities may contribute to the increased risk of cardiovascular disease. The aim of the present study was to compare arterial stiffness parameters and laboratory parameters between severe OSA patients and healthy control subjects.
Patients and methods: This study included 70 participants in total, 35 OSA patients and 35 healthy controls. All OSA patients...
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Arterijska elastičnost u osoba s predijabetesom i dijabetesom tipa 2
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Suzana Balić Cilj:
Glavni cilj istraživanja bio je ispitati arterijsku elastičnost kod osoba s predijabetesom i dijabetesom tipa 2 i usporediti s elastičnosti kod osoba s normalnom regulacijom glukoze te na taj način utvrditi postoji li povezanost između smanjenja elastičnosti arterijske stijenke i stanja predijabetesa.
Metode:
Ovo istraživanje je presječno prema svojem ustroju i uključilo je ukupno 358 ispitanika. Prikupljanje podataka provedeno je tijekom rujna 2013. g. do svibnja 2014....
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Artroskopsko liječenje ozljeda meniska u Zavodu za dječju kirurgiju KBC Split od 2006. - 2016. godine
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Ema Puizina Cilj istraživanja: Incidencija ozljeda meniska je u porastu u pedijatrijskoj populaciji. Postoje snažni dokazi da meniscektomija u djece pospješuje razvoj osteoartritisa koljena, pa su se tako u proteklih dvadeset godina tehnike popravka ruptura meniska razvile u smjeru očuvanja tkiva i funkcije meniska. Cilj ovog istraživanja je bio analizirati epidemiološke, demografske, kliničke karakteristike i ishod bolesnika operiranih zbog ozljeda meniska te unutar ispitanika usporediti dvije...
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Assesment of quality of life in patients with ulcerative colitis
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Alvaro Gomez Objectives: Adaptation to ulcerative colitis (UC) is very complex as it has a huge impact in the quality of life of those who suffer with it. In the present study the objective was to determine the differences in quality of life between UC patients and a control group.
Patients and Methods: This study included 30 patients with ulcerative colitis and 30 age and sex-matched control subjects. The diagnosis was based on medical history in addition to clinical, radiological, endoscopic and...
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Assessment of adverse drug reaction reports : metformin and metformin fixed drug combinations
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Ina Larsen Matić Objectives: The aim of the present study was to compare adverse drug reaction reports of metformin and metformin in fixed combination in Croatia from 2007 to 2018.
Materials and Methods: The data of adverse drug reaction reports received from 1 January 2007 to 31 December 2018 was analyzed in this retrospective study. Metformin reports were categorized into two main groups: single‐drug formulations and fixed‐dose combinations of drugs. The data of the year of the adverse drug...
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Assessment of nutritional status and nutritional habits in patients on hemodialysis
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Lars Brake Objectives: CKD is a pathological condition characterized by a progressive decline of renal function. It frequently results in ESRD which will require HD. The aim of this study was to assess nutritional status and adherence to Mediterranean diet in patients on hemodialysis treatment.
Materials and methods: The study included the 55 patients on HD treatment for at least 6 months that were older than 18 years. Venous blood samples were taken for evaluation of laboratory parameters. All...
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Assessment of nutritional status and quality of life in patients with percutaneous endoscopic gastrostomy
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Borna Lojpur Objectives : The main objectives of this study were to assess nutritional status and quality of life of patients who are enterally feeding via percutaneous endoscopic gastrostomy for a period of at least 3 months in the home environment.
Materials and methods: This study included a total of 31 participants, aged between 21 and 85 years, who have been feeding via percutaneous endoscopic gastrostomy for a period of at least 3 months in the home environment. Quality of life was assessed by...
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