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master's thesis
Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga
2012. urn:nbn:hr:171:450440
Benzon, Benjamin
University of Split
School of Medicine

Cite this document

Benzon, B. (2012). Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:450440

Benzon, Benjamin. "Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga." Master's thesis, University of Split, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:171:450440

Benzon, Benjamin. "Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga." Master's thesis, University of Split, School of Medicine, 2012. https://urn.nsk.hr/urn:nbn:hr:171:450440

Benzon, B. (2012). 'Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga', Master's thesis, University of Split, School of Medicine, accessed 15 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:450440

Benzon B. Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga [Master's thesis]. Split: University of Split, School of Medicine; 2012 [cited 2024 November 15] Available at: https://urn.nsk.hr/urn:nbn:hr:171:450440

B. Benzon, "Polimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga", Master's thesis, University of Split, School of Medicine, Split, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:171:450440

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Metadata
TitlePolimorfizam gena endoltelne sintaze dušičnog monoksida rs1800779 i njegova povezanost s nastankom perinatalnog hipoksično-ishemijskoga oštećenja mozga
Title (english)Association of NOS3 gene polymorphism rs1800779 with hypoxic-ischemic encephalopathy
AuthorBenjamin Benzon
MentorTatijana Zemunik (mentor)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2012, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Cilj istarživanja: Ispitati je li polimorfizam rs1800779 NOS3 gena povezan s perinatalnom hipoksično-ishemijskom ozljedom mozga (HIE). Ustroj istraživanja: Studija parova. Mjesto istraživanja: Laboratorij za medicinsku biologiju Medicinskog fakulteta u Splitu i Klinika za dječje bolesti KBC-a Split. Sudionici: U studij je 140 djece podijeljene po 70 u skupinu s HIE (prosječne gestacijske dobi (GD) 32.5 tjedna i prosječne porođajne mase (PM) 1899 g, s 46 muške i 24 ženske djece) i kontrolnu skupinu (posječne GD 32.3 tjedna i prosječne PM 1810 g, s 34 muške i 36 ženske djece). Da bi bila svrstana u skupinu s HIE djeca su morala zadovoljiti sljedeće kriterije: - Barem jedno od : deficiti u neurološkom statusu u prva 72 sata nakon poroda, frekvenciju srca pri porodu manju od 100 ili veću od 160 otkucaja u minuti, Apgar zbroj manji od 7 u petoj minuti nakon poroda, potrebu za oživljavanjem nakon poroda, pH arterijske krvi iz pupkovine manji od 7.1. - Pozitivan ultrazvučni nalaz hipoksično-ishemijskog oštećenja mozga. Djeca koja su imala prirođene malformacije središnjeg živčanog susutava (SŽS), infekcije SŽS, metaboličke bolesti, kromosomske abnormalnosti, koja su pretrpila traumu u pri porodu, djeca majki koje su bolovale od preeklampsije, djeca čije su majke imale abrupciju placente te djeca iz višeplodnih trudnoća nisu uključivana u studiju. Kontrolnu skupinu su sačinjavala djeca koja nakon dvije godine života nisu imali nikakvih neuroloških problema. Skpine su uparane po spolu i gestacijskoj dobi. Glavne mjere ishoda : Alelska i genostipska povezanost polimorfizma rs1800997 gena NOS3 i HIE. Rezultati: Ne postoji alelska (P=0.809) ni genotipska (P=0.729) povezanost polimorfizma rs1800997 gena NOS3 i HIE. Zaključak: Studija nije pokazala povezanost polimorfizama rs1800779 gena NOS3 i perinatalne hipoksično-ishemijske ozljede mozga, vjerojatno zbog toga što drugi promotori gena NOS3 i ostali čimbenici vazodilatacije uspiju kompenzirati posredan učinak polimorfizma rs1800779 na vazodilataciju, ali se njegov učinak ne može u potpunosti isključiti zbog male snage studije i malog uzorka.
Abstract (english)
Objective: To test associtation between NOS3 gene polymorphism rs1800779 and hypoxicischemic encephalopathy (HIE). Design: genecitc association study, population-based case-control study. Settings: Univeristy hospital Split and Department of medical biology, University of Split School of medicine Participants: Study included 140 chlidren devided in two groups. HIE group had 70 (46 male, 24 female) children with average gestationa age (GA) of 33.5 weeks (wk) and average birth weight (BW) of 1890 g, control goup had also 70 children (34 male, 36 female) with average GA of 33.1 wk. and average BW of 1810 g. To be included in HIE group participans had to met followig criteria:  At least one of : abnormality in neurogical status in first 72h, fetal heart rate in labour <100 bpm or >160bpm, Apgar score <7 in 5th minute after delivery, need for cardiopulmonary rescucitation after delivery, pH of blood sampeled from umbilical artery <7.1  Postive ultarsound findings for HIE. Childre with congenital malformations of central nervous system (CNS), CNS infection, metabolical diseases, chromosome abnormalities, those who suffered trauma during labor, children from pre/eclamptic pregnecies, children whose mother suffered abruptio placente during delivery and those from multifetal pregnacies were exluded from study. Children who have had no neurologic abnormalities after 2nd year of life were included in control group. Cases and contros were mached by gestational age and gender. Main outcome measures: Alellic and genotype association of NOS3 gene polymorhism rs1800779 with HIE. Results: No allelic nor genotype association between NOS3 gene polymorhism rs1800779 and HIE were found. Conclusion: Study did not show association of NOS3 gene polymorphism rs1800779 with HIE, but due to small sample size and inadequate study power, effect of rs1800779 on HIE can not be definetly excluded.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:450440
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-05-24 07:06:15