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master's thesis
PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS
2019. urn:nbn:hr:171:424430
Marušić, Filip
University of Split
School of Medicine
Pathophysiology

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Marušić, F. (2019). PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:424430

Marušić, Filip. "PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:424430

Marušić, Filip. "PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS." Master's thesis, University of Split, School of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:171:424430

Marušić, F. (2019). 'PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS', Master's thesis, University of Split, School of Medicine, accessed 31 May 2023, https://urn.nsk.hr/urn:nbn:hr:171:424430

Marušić F. PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS [Master's thesis]. Split: University of Split, School of Medicine; 2019 [cited 2023 May 31] Available at: https://urn.nsk.hr/urn:nbn:hr:171:424430

F. Marušić, "PARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS", Master's thesis, University of Split, School of Medicine, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:171:424430

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Metadata
TitlePARAMETERS OF IRON METABOLISM IN ACUTELY DECOMPENSATED HEART FAILURE PATIENTS
Title (croatian)PARAMETRI METABOLIZMA ŽELJEZA U PACIJENATA S AKUTNO DEKOMPENZIRANIM SRČANIM ZATAJENJEM
AuthorFilip Marušić
MentorJoško Božić (mentor)
Committee memberRenata Pecotić (predsjednik povjerenstva)
Committee memberDuška Glavaš (član povjerenstva)
Committee memberDaniela Šupe-Domić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathophysiology)
Split
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract
Objectives: The aim of the study was to compare how many patients with acute decompensated heart failure have iron deficiency or anemia and laboratory data between patients with acute decompensated heart failure when divided in groups based on iron and anemic status. Material and methods: This was a clinical, cross-sectional study, conducted between January 2018 and January 2019, that included a total of 60 consecutive patients with acute decompensation of chronic heart failure at Department of Cardiology of the University Hospital of Split. Upon patient’s arrival to hospital systolic and diastolic blood pressure was measured. Venous blood sampling was performed within 24 hours of admission. Chemiluminescent Microparticle Immunoassay was used for quantitative determination of ferritin. For serum iron spectrophotometry with ferrous chromogen was used. Complete blood count was determined using standard flow-cytometry-based hematologic analysis. Results: In this study the majority of patients had anemia and/or iron deficiency. Anemia without iron deficiency (22% of sample or 59% of anemic patients) was more prevalent than anemia with iron deficiency (15% of total population or 41% of anemic patients). There was significant difference in DBP between the groups with the lowest DBP observed in patients with anemia and iron deficiency (P=0.010). In patients with acute decompensated heart failure and anemia or iron deficiency higher levels of urea (P=0.031) and creatinine (P=0.020) were observed than in other subgroups. There was no significant difference in biochemical tests between groups. Conclusion: A significant number of patients hospitalized due to acute decompensated heart failure have anemia and/or iron deficiency. Diastolic blood pressure was lowest in patients with anemia and iron deficiency compared to other groups. Further research is necessary to draw any conclusions.
Abstract (croatian)
Ciljevi: Cilj ovog istraživanja je ispitati koliki broj pacijenata s akutno dekompenziranim srčanim zatajenjem boluje od anemije ili manjka željeza te usporediti laboratorijske nalaze između različitih skupina pacijenata podijeljenih prema statusu željeza i anemije. Materijali i metode: Presječno istraživanje je provedeno u periodu od siječnja 2018. do siječnja 2019, a uključivalo je 60 pacijenata s akutnom dekompenzacijom kroničnog srčanog zatajenja na Odjelu za kardiologiju Kliničkog bolničkog centra Split. Pacijentima je nakon prijema na odjel izmjeren sistolički i dijastolički krvni tlak. Uzorak venske krvi uzet je 24 sata nakon prijema. Kemiluminiscentna imunokemijska tehnologija korištena je za kvantitativno određivanje feritina u serumu. Spektrofotometrijska metoda s feren kromogenom korištena je za željezo u serumu. Kompletna krvna slika određena je protočnom citometrijom. Rezultati: U ovom istraživanju većina je pacijenata imala anemiju i/ili manjak željeza. Anemija bez manjka željeza (22 % svih pacijenata, 59% pacijenata s anemijom) bila je učestalija od anemije s manjkom željeza (15 % svih pacijenata, 49% pacijenata s anemijom). Uočena je značajna razlika u vrijednostima dijastoličkog krvnog tlaka između skupina pacijenata, a najmanje vrijednosti bile su u skupini pacijenata s anemijom i manjkom željeza (P=0,010). U pacijenata s akutno dekompenziranim zatajenjem srca i anemijom ili nedostatkom željeza uočene su više serumske koncentracije ureje (P= 0,031) i kreatinina (P=0,020) nego kod ostalih ispitanika. Nije pronađena značajna razlika između skupina u vrijednostima biokemijskih testova. Zaključak: Značajan udio pacijenata koji su hospitalizirani zbog akutno dekompenziranog srčanog zatajenjua imaju anemiju i/ili manjak željeza. Vrijednosti dijastoličkog krvnog tlaka značajno su bile niže u pacijenata s anemijom i/ili manjkom željeza u usporedbi s pacijentima koji nisu bili anemični niti su imali manjak željeza. Daljnja istraživanja su potrebna kako bi se mogli donositi zaključci.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:424430
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-21 15:23:57